Cell Senescence Entries for HDAC2
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Harms et al. (2007) Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity. Cancer Res 67(7)3145-52 (PubMed)
HDAC2 Gene Information
- HGNC symbol
- HDAC2
- Aliases
- KDAC2; RPD3; YAF1
- Common name
- histone deacetylase 2
- Entrez Id
- 3066
- Description
- This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
HDAC2 Ontologies
- Gene Ontology
-
Process: GO:6325; chromatin organization
GO:16575; histone deacetylation
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:6338; chromatin remodeling
GO:8284; positive regulation of cell population proliferation
GO:43066; negative regulation of apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
And 47 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:785; chromatin
GO:781; chromosome, telomeric region
GO:118; histone deacetylase complex
GO:35098; ESC/E(Z) complex
GO:16581; NuRD complex
GO:16580; Sin3 complex
GO:16020; membrane
And 2 more GO terms Function: GO:5515; protein binding
GO:3723; RNA binding
GO:16787; hydrolase activity
GO:19899; enzyme binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
GO:3682; chromatin binding
GO:19213; deacetylase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:33558; protein deacetylase activity
GO:51059; NF-kappaB binding
And 5 more GO terms
Homologs of HDAC2 in Model Organisms
- Caenorhabditis elegans
- hda-1
- Caenorhabditis elegans
- hda-3
- Drosophila melanogaster
- Rpd3
- Mus musculus
- Hdac2
- Rattus norvegicus
- Hdac2
- Saccharomyces cerevisiae
- RPD3
- Schizosaccharomyces pombe
- clr6
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as HDAC2
- GenDR gene manipulations
External links
- OMIM
- 605164
- Ensembl
- ENSG00000196591
- Entrez Gene
- 3066
- UniGene
- 3352
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HDAC2
- GeneCards
- HDAC2