Cell Senescence Entries for HDAC2

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Harms et al. (2007) Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity. Cancer Res 67(7)3145-52 (PubMed)

HDAC2 Gene Information

HGNC symbol
HDAC2 
Aliases
KDAC2; RPD3; YAF1 
Common name
histone deacetylase 2 
Entrez Id
3066
Description
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].

HDAC2 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:16575; histone deacetylation
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:6338; chromatin remodeling
GO:8284; positive regulation of cell population proliferation
GO:43066; negative regulation of apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
And 47 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:785; chromatin
GO:781; chromosome, telomeric region
GO:118; histone deacetylase complex
GO:35098; ESC/E(Z) complex
GO:16581; NuRD complex
GO:16580; Sin3 complex
GO:16020; membrane
And 2 more GO terms
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:16787; hydrolase activity
GO:19899; enzyme binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
GO:3682; chromatin binding
GO:19213; deacetylase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:33558; protein deacetylase activity
GO:51059; NF-kappaB binding
And 5 more GO terms
Show all GO terms

Homologs of HDAC2 in Model Organisms

Caenorhabditis elegans
hda-1
Caenorhabditis elegans
hda-3
Drosophila melanogaster
Rpd3
Mus musculus
Hdac2
Rattus norvegicus
Hdac2
Saccharomyces cerevisiae
RPD3
Schizosaccharomyces pombe
clr6

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
  • A homolog of this gene for Drosophila melanogaster is present as Rpd3
GenAge human genes
  • This gene is present as HDAC2
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as Rpd3
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3

External links

OMIM
605164
Ensembl
ENSG00000196591
Entrez Gene
3066
UniGene
3352
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HDAC2
GeneCards
HDAC2