Saccharomyces cerevisiaeGenAge entry for RPD3 (Saccharomyces cerevisiae)

Gene information (ID: 555)

Symbol
RPD3
Aliases
MOF6; REC3; SDI2; SDS6
Name
Histone deacetylase
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Regulates transcription and silencing

Potential relevance to longevity and/or ageing

Observations
Deletion extended lifespan by 41%, independently of an intact Sir silencing complex.
% change in avg or median lifespan
Lifespan is 41% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Rpd3
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as HDAC1
    • A homolog of this gene for Homo sapiens is present as HDAC2
    • A homolog of this gene for Homo sapiens is present as HDAC3
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Rpd3
    • This gene is present as RPD3
    CellAge
    • A homolog of this gene for Homo sapiens is present as HDAC1
    • A homolog of this gene for Homo sapiens is present as HDAC2
    • A homolog of this gene for Homo sapiens is present as HDAC3

    Homologs in other organisms

    Caenorhabditis elegans
    hda-3
    Caenorhabditis elegans
    hda-1
    Danio rerio
    hdac1
    Danio rerio
    hdac3
    Danio rerio
    hdac8
    Drosophila melanogaster
    Hdac3
    Drosophila melanogaster
    Rpd3
    Homo sapiens
    HDAC2
    Homo sapiens
    HDAC3
    Homo sapiens
    HDAC8
    Homo sapiens
    HDAC1
    Mus musculus
    Hdac1
    Mus musculus
    Hdac8
    Mus musculus
    Hdac2
    Mus musculus
    Hdac3
    Mus musculus
    Gm10093
    Rattus norvegicus
    Hdac1l
    Rattus norvegicus
    Hdac1
    Rattus norvegicus
    Hdac8
    Rattus norvegicus
    Hdac2
    Rattus norvegicus
    Hdac3
    Schizosaccharomyces pombe
    clr6

    External links

    Saccharomyces Genome Database
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (855386)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar