The SIRT1 gene and its putative association with human ageing

Cell Types

Lung fibroblast

Cell Lines

2BS

Cancer Cell?

No

Method

Overexpression

Type of senescence

Unclear

Senescence Effect

Inhibits

Primary Reference

Huang et al. (2008) SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS One 3(3)e1710 (PubMed)

HGNC symbol

SIRT1

Aliases

SIR2L1

Common name

sirtuin 1

Entrez Id

23411

Description

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].

Gene Ontology

Process:

GO:2000773; negative regulation of cellular senescence
GO:43066; negative regulation of apoptotic process
GO:16567; protein ubiquitination
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:720; pyrimidine dimer repair by nucleotide-excision repair
GO:731; DNA synthesis involved in DNA repair
GO:1525; angiogenesis
GO:1542; ovulation from ovarian follicle
GO:1678; cellular glucose homeostasis
GO:1934; positive regulation of protein phosphorylation
GO:6476; protein deacetylation
GO:6642; triglyceride mobilization
GO:7283; spermatogenesis
GO:7623; circadian rhythm
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:9267; cellular response to starvation
GO:10875; positive regulation of cholesterol efflux
GO:10883; regulation of lipid storage
GO:10906; regulation of glucose metabolic process
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:16239; positive regulation of macroautophagy
GO:16575; histone deacetylation
GO:30225; macrophage differentiation
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:31393; negative regulation of prostaglandin biosynthetic process
GO:31648; protein destabilization
GO:32007; negative regulation of TOR signaling
GO:32868; response to insulin
GO:32922; circadian regulation of gene expression
GO:33210; leptin-mediated signaling pathway
GO:34391; regulation of smooth muscle cell apoptotic process
GO:35356; cellular triglyceride homeostasis
GO:35358; regulation of peroxisome proliferator activated receptor signaling pathway
GO:42326; negative regulation of phosphorylation
GO:42595; behavioral response to starvation
GO:42632; cholesterol homeostasis
GO:43065; positive regulation of apoptotic process
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:44321; response to leptin
GO:45599; negative regulation of fat cell differentiation
GO:45722; positive regulation of gluconeogenesis
GO:45944; positive regulation of transcription by RNA polymerase II
GO:50872; white fat cell differentiation
GO:51152; positive regulation of smooth muscle cell differentiation
GO:51898; negative regulation of protein kinase B signaling
GO:55089; fatty acid homeostasis
GO:60907; positive regulation of macrophage cytokine production
GO:61647; histone H3-K9 modification
GO:70857; regulation of bile acid biosynthetic process
GO:71479; cellular response to ionizing radiation
GO:90335; regulation of brown fat cell differentiation
GO:106230; protein depropionylation
GO:1900113; negative regulation of histone H3-K9 trimethylation
GO:1901215; negative regulation of neuron death
GO:1902166; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1902237; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1904179; positive regulation of adipose tissue development
GO:1990619; histone H3-K9 deacetylation
GO:1990830; cellular response to leukemia inhibitory factor
GO:2000111; positive regulation of macrophage apoptotic process
GO:2000481; positive regulation of cAMP-dependent protein kinase activity
GO:30154; cell differentiation
GO:7517; muscle organ development
GO:6974; cellular response to DNA damage stimulus
GO:48511; rhythmic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:8284; positive regulation of cell population proliferation
GO:45739; positive regulation of DNA repair
GO:42981; regulation of apoptotic process
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:71356; cellular response to tumor necrosis factor
GO:1938; positive regulation of endothelial cell proliferation
GO:10629; negative regulation of gene expression
GO:7346; regulation of mitotic cell cycle
GO:6979; response to oxidative stress
GO:45766; positive regulation of angiogenesis
GO:42542; response to hydrogen peroxide
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:71456; cellular response to hypoxia
GO:46628; positive regulation of insulin receptor signaling pathway
GO:42771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:30308; negative regulation of cell growth
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:183; rDNA heterochromatin assembly
GO:31062; positive regulation of histone methylation
GO:31065; positive regulation of histone deacetylation
GO:42149; cellular response to glucose starvation
GO:45786; negative regulation of cell cycle
GO:46015; regulation of transcription by glucose
GO:97009; energy homeostasis
GO:10824; regulation of centrosome duplication
GO:43518; negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:60766; negative regulation of androgen receptor signaling pathway
GO:1900034; regulation of cellular response to heat
GO:7179; transforming growth factor beta receptor signaling pathway
GO:1902176; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:42127; regulation of cell population proliferation
GO:51097; negative regulation of helicase activity
GO:45348; positive regulation of MHC class II biosynthetic process
GO:70301; cellular response to hydrogen peroxide
GO:32071; regulation of endodeoxyribonuclease activity
GO:12; single strand break repair
GO:51574; positive regulation of histone H3-K9 methylation
GO:2000774; positive regulation of cellular senescence
GO:70932; histone H3 deacetylation
GO:34983; peptidyl-lysine deacetylation
GO:18394; peptidyl-lysine acetylation
GO:70914; UV-damage excision repair
GO:2821; positive regulation of adaptive immune response
GO:31507; heterochromatin assembly
GO:6346; DNA methylation-dependent heterochromatin assembly
GO:7569; cell aging
GO:71441; negative regulation of histone H3-K14 acetylation
GO:71900; regulation of protein serine/threonine kinase activity
GO:90400; stress-induced premature senescence
GO:1901984; negative regulation of protein acetylation
GO:2000480; negative regulation of cAMP-dependent protein kinase activity
GO:2000619; negative regulation of histone H4-K16 acetylation
GO:2000655; negative regulation of cellular response to testosterone stimulus
GO:2000757; negative regulation of peptidyl-lysine acetylation

Cellular component:

GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1650; fibrillar center
GO:5739; mitochondrion
GO:785; chromatin
GO:792; heterochromatin
GO:32991; protein-containing complex
GO:5637; nuclear inner membrane
GO:16605; PML body
GO:35098; ESC/E(Z) complex
GO:5730; nucleolus
GO:5635; nuclear envelope
GO:33553; rDNA heterochromatin
GO:61773; eNoSc complex
GO:5677; chromatin silencing complex
GO:791; euchromatin

Function:

GO:5515; protein binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:2039; p53 binding
GO:3713; transcription coactivator activity
GO:3714; transcription corepressor activity
GO:17136; NAD-dependent histone deacetylase activity
GO:19213; deacetylase activity
GO:19899; enzyme binding
GO:19904; protein domain specific binding
GO:33558; protein deacetylase activity
GO:34979; NAD-dependent protein deacetylase activity
GO:46969; NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:70403; NAD+ binding
GO:106231; protein-propionyllysine depropionylase activity
GO:1990841; promoter-specific chromatin binding
GO:140297; DNA-binding transcription factor binding
GO:8022; protein C-terminus binding
GO:42393; histone binding
GO:43425; bHLH transcription factor binding
GO:42802; identical protein binding
GO:16922; nuclear receptor binding
GO:51019; mitogen-activated protein kinase binding
GO:1990254; keratin filament binding
GO:4407; histone deacetylase activity
GO:43398; HLH domain binding

Hide GO terms

Caenorhabditis elegans

sir-2.1

Danio rerio

sirt1

Drosophila melanogaster

Sir2

Mus musculus

Sirt1

Rattus norvegicus

Sirt1

Saccharomyces cerevisiae