LongevityMap variant
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- Six hundred seventy-seven participants (289 males and 388 females) between 16 and 104 years of age, categorized as long lived (LL; >85 years old) or controls (C; <85 years old), were genotyped for Gly1057Asp-IRS2 locus variability (rs1805097)
- Conclusions
- Homozygous IRS2(Asp/Asp) participants were more represented among LL versus C participants (16.7% vs 12.0%; p = .04) and were more likely to reach extreme old age (>/=90 percentile, 96-104 years; odds ratio: 2.03, 95% CI = 1.39-2.99;p = .0003). The association between IRS2 gene polymorphism with longevity (being LL) was independent of anthropometric and metabolic covariates (odds ratio: 2.07, 95% confidence interval [CI] = 1.38-3.12; p = .001).
- HGNC symbol
- IRS2
- Aliases
- IRS-2
- Common name
- insulin receptor substrate 2
- Description
- This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 1
- OMIM
- 600797
- Ensembl
- ENSG00000185950
- UniProt/Swiss-Prot
- IRS2_HUMAN
- Entrez Gene
- 8660
- UniGene
- 442344
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- irs2a
- Danio rerio
- irs2b
- Drosophila melanogaster
- chico
- Mus musculus
- Irs2
- Rattus norvegicus
- Irs2
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as chico
- A homolog of this gene for Mus musculus is present as Irs2
- GenAge human genes
- This gene is present as IRS2
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Irs2
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as chico
Barbieri et al. (2010)
Other variants which are also part of this study
