Mus musculusGenAge entry for Irs2 (Mus musculus)

Gene information (ID: 378)

Symbol
Irs2
Aliases
Irs-2
Name
insulin receptor substrate 2
Organism
Mus musculus (AnAge)
Known functions and activities
Cytoplasmic signalling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines

Potential relevance to longevity and/or ageing

Observations
Irs2 brain-specific knockout mice were overweight, hyperinsulinemic, glucose intolerant, yet more active and lived up to 18% longer.
% change in avg or median lifespan
Lifespan is 18% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as IRS2
    GenDR gene expression
    • This gene is present as Irs2
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as IRS2

    Homologs in other organisms

    Danio rerio
    zgc:56306
    Homo sapiens
    IRS2
    Rattus norvegicus
    Irs2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (384783)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar