Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: let-363

Gene Information (Entrez Gene ID: 172167)

Symbol
let-363
Name
LEThal 363
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
172167

Potential relevance to dietary restriction and ageing

Observations

let-363 RNAi significantly extends the lifespan of wild-type, but does not further extend the long lifespan of eat-2 mutant [2312]. let-363 RNAi led to an average increase in lifespan of 8% in wild-type and 3% in eat-2 background, suggesting let-363 works synergistically with eat-2 mutation [2494]. Another study showed that DR fails to significantly extend lifespan of let-363 RNAi-treated animals [2566].

References

    In other databases

    GenAge model organism genes
    • This gene is present as let-363
    • A homolog of this gene for Drosophila melanogaster is present as Tor
    • A homolog of this gene for Saccharomyces cerevisiae is present as TOR1
    • A homolog of this gene for Mus musculus is present as Mtor
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as MTOR
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as TOR1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as MTOR

    Homologs

    Danio rerio
    mtor
    Drosophila melanogaster
    Tor
    Homo sapiens
    MTOR
    Mus musculus
    Mtor
    Rattus norvegicus
    Mtor
    Saccharomyces cerevisiae
    TOR1
    Schizosaccharomyces pombe
    tor1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 172167
    Homologues
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    UniProt
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    Internet
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