Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: sir-2.1

Gene Information (Entrez Gene ID: 177924)

Symbol
sir-2.1
Name
Yeast SIR related 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
177924

Potential relevance to dietary restriction and ageing

Observations

sir-2.1 deletion slightly reduces lifespan of wild-type [2296]. sir-2.1 overexpression extends lifespan by about 50% and this lifespan extension depends on DAF-16 activity and it does not synergize with daf-2 [199]. sir-2.1 suppresses longevity of eat-2 mutants, but not daf-2 mutants. sir-2.1 is therefore partially required for lifespan extension from mutation of eat-2 [2296], but is completely independent for lifespan extension from DR using a reduced feeding protocol [3446]. Solid DR increases lifespan of wild-type and sir-2.1 mutants to the same extent [2568].

References

    In other databases

    GenAge model organism genes
    • This gene is present as sir-2.1
    • A homolog of this gene for Drosophila melanogaster is present as Sir2
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
    • A homolog of this gene for Mus musculus is present as Sirt1
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SIRT1
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Sir2
    • A homolog of this gene for Mus musculus is present as Sirt1
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SIRT1
    CellAge
    • A homolog of this gene for Homo sapiens is present as SIRT1

    Homologs

    Danio rerio
    sirt1
    Drosophila melanogaster
    Sir2
    Homo sapiens
    SIRT1
    Mus musculus
    Sirt1
    Rattus norvegicus
    Sirt1
    Saccharomyces cerevisiae
    HST1
    Saccharomyces cerevisiae
    SIR2
    Schizosaccharomyces pombe
    hst2

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 177924
    Homologues
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    UniProt
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    Internet
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