Caenorhabditis elegansGenAge entry for sir-2.1 (Caenorhabditis elegans)

Gene information (ID: 604)

Symbol
sir-2.1
Name
Yeast SIR related (68.8 kD) (sir-2.1)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
NAD(+)-dependent histone deacetylase that silences gene expression

Potential relevance to longevity and/or ageing

Observations
Overexpression of sir-2.1 extended lifespan.
% change in max lifespan
Maximum lifespan is 15% higher.
% change in avg or median lifespan
Average lifespan is 10% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Outcrossing of lines with sir-2.1 overexpression abrogated the lifespan increase.
    Lifespan Effect
    Noeffect
    Longevity Category
    Not Recorded
    Primary reference
      Observations
      Overexpression extends lifespan by about 50%.
      % change in avg or median lifespan
      Lifespan is about 50% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Overexpression
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        Sir-2.1(ok434) mutants show a slight decrease in lifespan as well as sensitivity to various stresses.
        Lifespan Effect
        Decrease
        Genetic Manipulation
        Mutation
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Saccharomyces cerevisiae is present as HST2
          • A homolog of this gene for Mus musculus is present as Sirt1
          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as SIRT1
          GenDR gene manipulations
          • A homolog of this gene for Mus musculus is present as Sirt1
          • This gene is present as sir-2.1
          • A homolog of this gene for Saccharomyces cerevisiae is present as HST2
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as SIRT1
          CellAge
          • A homolog of this gene for Homo sapiens is present as SIRT1

          Homologs in other organisms

          Danio rerio
          sirt1
          Homo sapiens
          SIRT1
          Mus musculus
          Sirt1
          Rattus norvegicus
          Sirt1
          Saccharomyces cerevisiae
          HST2
          Schizosaccharomyces pombe
          hst2

          External links

          WormBase
          Search
          Ensembl
          Search
          Entrez Gene
          View on Entrez Gene database (177924)
          Homologues
          Search HomoloGene
          UniProt
          Search
          Internet
          Search Google or Search Google Scholar