LongevityMap Gene
Gene details
- HGNC symbol
- PRDX3
- Aliases
- AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III
- Common name
- peroxiredoxin 3
- Description
- This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
- Cytogenetic Location
- 10q26.11
- UCSC Genome Browser
- View 10q26.11 on the UCSC genome browser
- OMIM
- 604769
- Ensembl
- ENSG00000165672
- UniProt/Swiss-Prot
- PRDX3_HUMAN
- Entrez Gene
- 10935
- UniGene
- 523302
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- prdx-3
- Danio rerio
- prdx3
- Drosophila melanogaster
- Prx3
- Mus musculus
- Prdx3
- Rattus norvegicus
- Prdx3
- Saccharomyces cerevisiae
- TSA1
- Saccharomyces cerevisiae
- TSA2
In other databases
- GenAge model organism genes
- GenAge microarray genes
- This gene is present as PRDX3
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as TSA1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs11198811
- Reference