Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: TSA1

Gene Information (Entrez Gene ID: 854980)

Symbol
TSA1
Aliases
TPX1 ZRG14
Name
Thiol-Specific Antioxidant 1
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
854980

Potential relevance to dietary restriction and ageing

Observations

Disruption of TSA1 shortens chronological lifespan [2633]. Replicative lifespan extension by DR in sir2;fob1 double mutant is reduced by TSA1 deletion mutant. Wild-type cells require TSA1 to fully extend lifespan. Mutation in CDC35 (adenylate cyclase), a genetic mimetic of DR, is dependent on TSA1 to extend lifespan [2587].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as prdx-2
    • A homolog of this gene for Caenorhabditis elegans is present as prdx-3
    • A homolog of this gene for Mus musculus is present as Prdx1
    • A homolog of this gene for Drosophila melanogaster is present as Jafrac1
    • This gene is present as TSA1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PRDX1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PRDX3

    Homologs

    Caenorhabditis elegans
    prdx-2
    Caenorhabditis elegans
    prdx-3
    Danio rerio
    prdx1
    Danio rerio
    prdx3
    Danio rerio
    prdx4
    Danio rerio
    prdx2
    Drosophila melanogaster
    Jafrac2
    Drosophila melanogaster
    Jafrac1
    Drosophila melanogaster
    CG6888
    Drosophila melanogaster
    Prx3
    Homo sapiens
    PRDX3
    Homo sapiens
    PRDX2
    Homo sapiens
    PRDX4
    Homo sapiens
    PRDX1
    Mus musculus
    Prdx3
    Mus musculus
    Prdx1
    Mus musculus
    Gm5225
    Mus musculus
    Prdx4
    Mus musculus
    Prdx2
    Rattus norvegicus
    Prdx4
    Rattus norvegicus
    AABR07012795.1
    Rattus norvegicus
    Prdx3
    Rattus norvegicus
    Prdx2
    Rattus norvegicus
    Prdx1

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 854980
    Homologues
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    UniProt
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    Internet
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