LongevityMap Gene
Gene details
- HGNC symbol
- GSTP1
- Aliases
- PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
- Common name
- glutathione S-transferase pi 1
- Description
- Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 11q13.2
- UCSC Genome Browser
- View 11q13.2 on the UCSC genome browser
- OMIM
- 134660
- Ensembl
- ENSG00000084207
- UniProt/Swiss-Prot
- GSTP1_HUMAN
- Entrez Gene
- 2950
- UniGene
- 523836
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- gst-23
- Caenorhabditis elegans
- gst-25
- Caenorhabditis elegans
- gst-41
- Caenorhabditis elegans
- gst-1
- Danio rerio
- gstp2
- Danio rerio
- gstp1
- Mus musculus
- Gstp1
- Mus musculus
- Gstp2
- Rattus norvegicus
- Gstp1
In other databases
Studies (2)
Significant/Non-significant: 0/2
Study 1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- I105V SNP was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years
- Conclusions
- There were slightly fewer observed heterozygous 105IV genotypes and more homozygous 105VV genotypes
- Indentifier
- I105V
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs1138272
- Reference