LongevityMap variant group

Entry Details

Longevity Association
Non-significant
Population
Danish
Study Design
38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
Conclusions
No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.

Variants (282)

No gene

1.
Identifier
rs1001362
Cytogenetic Location
2.
Identifier
rs381689
Cytogenetic Location

ACOX1

1.
Identifier
rs1137582
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
2.
Identifier
rs11651351
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
3.
Identifier
rs12430
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
4.
Identifier
rs17583163
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
5.
Identifier
rs3643
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
6.
Identifier
rs3744032
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
7.
Identifier
rs3744033
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
8.
Identifier
rs7219716
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
9.
Identifier
rs7226127
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser
10.
Identifier
rs8065144
Cytogenetic Location
17q25.1
UCSC Genome Browser
View 17q25.1 on the UCSC genome browser

Gene details

HGNC symbol
ACOX1
Aliases
ACOX; SCOX; PALMCOX 
Common name
acyl-CoA oxidase 1 
Description
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
9
OMIM
609751
Ensembl
ENSG00000161533
UniProt/Swiss-Prot
ACOX1_HUMAN
Entrez Gene
51
UniGene
464137
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
F08A8.4
Caenorhabditis elegans
acox-5
Caenorhabditis elegans
F59F4.1
Caenorhabditis elegans
acox-3
Caenorhabditis elegans
acox-2
Caenorhabditis elegans
acox-1
Danio rerio
acox1
Drosophila melanogaster
CG4586
Drosophila melanogaster
CG5009
Drosophila melanogaster
Acox57D-p
Drosophila melanogaster
Acox57D-d
Mus musculus
Acox1
Rattus norvegicus
Acox1
Saccharomyces cerevisiae
POX1

AOX1

1.
Identifier
rs10187029
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
2.
Identifier
rs10172572
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
3.
Identifier
rs10497866
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
4.
Identifier
rs11887334
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
5.
Identifier
rs1405984
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
6.
Identifier
rs16833921
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
7.
Identifier
rs17533245
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
8.
Identifier
rs2002957
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
9.
Identifier
rs2241080
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
10.
Identifier
rs2256977
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
11.
Identifier
rs2348021
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
12.
Identifier
rs2348023
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
13.
Identifier
rs2463489
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
14.
Identifier
rs2465661
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
15.
Identifier
rs2465665
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
16.
Identifier
rs2540066
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
17.
Identifier
rs2540069
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
18.
Identifier
rs2881811
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
19.
Identifier
rs4337457
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
20.
Identifier
rs4672866
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
21.
Identifier
rs6435060
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
22.
Identifier
rs6761375
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
23.
Identifier
rs7562507
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser
24.
Identifier
rs7587871
Cytogenetic Location
2q33.1
UCSC Genome Browser
View 2q33.1 on the UCSC genome browser

Gene details

HGNC symbol
AOX1
Aliases
AO; AOH1 
Common name
aldehyde oxidase 1 
Description
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
23
OMIM
602841
Ensembl
ENSG00000138356
UniProt/Swiss-Prot
AOXA_HUMAN
Entrez Gene
316
UniGene
406238
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
F15E6.6
Caenorhabditis elegans
F55B11.1
Caenorhabditis elegans
gad-3
Danio rerio
aox5
Drosophila melanogaster
AOX4
Drosophila melanogaster
AOX1
Drosophila melanogaster
ry
Drosophila melanogaster
AOX2
Drosophila melanogaster
AOX3
Mus musculus
Aox1
Rattus norvegicus
Aox1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as F55B11.1
  • A homolog of this gene for Drosophila melanogaster is present as ry
GenAge microarray genes
  • This gene is present as AOX1
CellAge gene expression
  • This gene is present as AOX1

CAT

1.
Identifier
rs10488736
In Other Studies (IDs)
2543
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
2.
Identifier
rs1049982
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
3.
Identifier
rs11032703
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
4.
Identifier
rs12273124
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
5.
Identifier
rs2300182
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
6.
Identifier
rs3758730
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
7.
Identifier
rs499406
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
8.
Identifier
rs566979
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
9.
Identifier
rs769214
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
10.
Identifier
rs769217
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
11.
Identifier
rs7933285
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser

Gene details

HGNC symbol
CAT
Aliases
 
Common name
catalase 
Description
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Other longevity studies of this gene
17
OMIM
115500
Ensembl
ENSG00000121691
UniProt/Swiss-Prot
CATA_HUMAN
Entrez Gene
847
UniGene
502302
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
ctl-2
Caenorhabditis elegans
ctl-3
Caenorhabditis elegans
ctl-1
Danio rerio
cat
Drosophila melanogaster
Cat
Drosophila melanogaster
CG9314
Mus musculus
Cat
Rattus norvegicus
Cat
Saccharomyces cerevisiae
CTA1
Schizosaccharomyces pombe
cta1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Cat
  • A homolog of this gene for Mus musculus is present as Cat
  • A homolog of this gene for Saccharomyces cerevisiae is present as CTA1
GenAge human genes
  • This gene is present as CAT

CP

1.
Identifier
rs13072552
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
2.
Identifier
rs13095262
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
3.
Identifier
rs17787768
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
4.
Identifier
rs17838831
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
5.
Identifier
rs3755642
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
6.
Identifier
rs4974389
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
7.
Identifier
rs701748
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
8.
Identifier
rs701753
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
9.
Identifier
rs701754
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
10.
Identifier
rs7652826
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
11.
Identifier
rs772908
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser
12.
Identifier
rs9853335
Cytogenetic Location
3q24-q25.1
UCSC Genome Browser
View 3q24-q25.1 on the UCSC genome browser

Gene details

HGNC symbol
CP
Aliases
CP-2 
Common name
ceruloplasmin 
Description
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Other longevity studies of this gene
11
OMIM
117700
Ensembl
ENSG00000047457
UniProt/Swiss-Prot
A5PL27_HUMAN
Entrez Gene
1356
UniGene
558314
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
cp
Mus musculus
Cp
Rattus norvegicus
Cp

In other databases

GenAge microarray genes
  • This gene is present as CP

CYC1

1.
Identifier
rs11780874
Cytogenetic Location
8q24.3
UCSC Genome Browser
View 8q24.3 on the UCSC genome browser
2.
Identifier
rs11784574
Cytogenetic Location
8q24.3
UCSC Genome Browser
View 8q24.3 on the UCSC genome browser

Gene details

HGNC symbol
CYC1
Aliases
UQCR4; MC3DN6 
Common name
cytochrome c1 
Description
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
Other longevity studies of this gene
1
OMIM
123980
Ensembl
ENSG00000179091
UniProt/Swiss-Prot
CY1_HUMAN
Entrez Gene
1537
UniGene
289271
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
cyc-1
Danio rerio
cyc1
Drosophila melanogaster
CG4769
Drosophila melanogaster
CG14508
Mus musculus
Cyc1
Rattus norvegicus
Cyc1
Saccharomyces cerevisiae
CYT1
Schizosaccharomyces pombe
cyt1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as cyc-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as CYT1
GenAge microarray genes
  • This gene is present as CYC1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as CYT1

CYP1B1

1.
Identifier
rs1056836
Cytogenetic Location
2p22.2
UCSC Genome Browser
View 2p22.2 on the UCSC genome browser
2.
Identifier
rs10916
Cytogenetic Location
2p22.2
UCSC Genome Browser
View 2p22.2 on the UCSC genome browser
3.
Identifier
rs162556
Cytogenetic Location
2p22.2
UCSC Genome Browser
View 2p22.2 on the UCSC genome browser
4.
Identifier
rs162557
Cytogenetic Location
2p22.2
UCSC Genome Browser
View 2p22.2 on the UCSC genome browser
5.
Identifier
rs1800440
Cytogenetic Location
2p22.2
UCSC Genome Browser
View 2p22.2 on the UCSC genome browser
6.
Identifier
rs2617266
Cytogenetic Location
2p22.2
UCSC Genome Browser
View 2p22.2 on the UCSC genome browser
7.
Identifier
rs4646429
Cytogenetic Location
2p22.2
UCSC Genome Browser
View 2p22.2 on the UCSC genome browser

Gene details

HGNC symbol
CYP1B1
Aliases
CP1B; ASGD6; GLC3A; CYPIB1; P4501B1 
Common name
cytochrome P450 family 1 subfamily B member 1 
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
7
OMIM
601771
Ensembl
ENSG00000138061
UniProt/Swiss-Prot
CP1B1_HUMAN
Entrez Gene
1545
UniGene
154654
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
cyp1b1
Drosophila melanogaster
Cyp18a1
Mus musculus
Cyp1b1
Rattus norvegicus
Cyp1b1

G6PD

1.
Identifier
rs2472393
Cytogenetic Location
Xq28
UCSC Genome Browser
View Xq28 on the UCSC genome browser
2.
Identifier
rs743544
Cytogenetic Location
Xq28
UCSC Genome Browser
View Xq28 on the UCSC genome browser

Gene details

HGNC symbol
G6PD
Aliases
G6PD1 
Common name
glucose-6-phosphate dehydrogenase 
Description
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
1
OMIM
305900
Ensembl
ENSG00000160211
UniProt/Swiss-Prot
G6PD_HUMAN
Entrez Gene
2539
UniGene
461047
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
gspd-1
Danio rerio
g6pd
Drosophila melanogaster
Zw
Mus musculus
G6pdx
Mus musculus
G6pd2
Rattus norvegicus
G6pd
Saccharomyces cerevisiae
ZWF1
Schizosaccharomyces pombe
zwf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Zw
  • A homolog of this gene for Saccharomyces cerevisiae is present as ZWF1
  • A homolog of this gene for Mus musculus is present as G6PD
GenAge microarray genes
  • This gene is present as G6PD
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as G6pdx
CellAge
  • This gene is present as G6PD

GCLC

1.
Identifier
rs12524494
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
2.
Identifier
rs16883912
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
3.
Identifier
rs16883966
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
4.
Identifier
rs2100375
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
5.
Identifier
rs2397147
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
6.
Identifier
rs4712035
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
7.
Identifier
rs531557
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
8.
Identifier
rs534957
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
9.
Identifier
rs572496
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
10.
Identifier
rs617066
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
11.
Identifier
rs661603
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
12.
Identifier
rs670548
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
13.
Identifier
rs675908
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser
14.
Identifier
rs7742367
Cytogenetic Location
6p12.1
UCSC Genome Browser
View 6p12.1 on the UCSC genome browser

Gene details

HGNC symbol
GCLC
Aliases
GCL; GCS; GLCL; GLCLC 
Common name
glutamate-cysteine ligase catalytic subunit 
Description
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
Other longevity studies of this gene
13
OMIM
606857
Ensembl
ENSG00000001084
UniProt/Swiss-Prot
E1CEI4_HUMAN
Entrez Gene
2729
UniGene
654465
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
gcs-1
Danio rerio
gclc
Drosophila melanogaster
Gclc
Mus musculus
Gclc
Rattus norvegicus
Gclc
Saccharomyces cerevisiae
GSH1
Schizosaccharomyces pombe
gcs1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Gclc
GenAge human genes
  • This gene is present as GCLC
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as GSH1

GLRX

1.
Identifier
rs1047420
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser
2.
Identifier
rs12513728
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser
3.
Identifier
rs2007
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser
4.
Identifier
rs3756704
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser
5.
Identifier
rs4561
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser
6.
Identifier
rs6556884
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser
7.
Identifier
rs871775
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser
8.
Identifier
rs9314160
Cytogenetic Location
5q15
UCSC Genome Browser
View 5q15 on the UCSC genome browser

Gene details

HGNC symbol
GLRX
Aliases
GRX; GRX1 
Common name
glutaredoxin 
Description
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
Other longevity studies of this gene
7
OMIM
600443
Ensembl
ENSG00000173221
UniProt/Swiss-Prot
A0A024RAM2_HUMAN
Entrez Gene
2745
UniGene
28988
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
glrx-10
Danio rerio
glrx
Mus musculus
Glrx
Rattus norvegicus
AC243283.1
Rattus norvegicus
AC242890.1
Rattus norvegicus
AC244836.1
Rattus norvegicus
Glrx
Rattus norvegicus
AC240814.1
Rattus norvegicus
LOC305806
Rattus norvegicus
AC242886.1
Rattus norvegicus
AC241705.1
Rattus norvegicus
AC241562.1
Rattus norvegicus
AC241244.1
Rattus norvegicus
AC242860.1
Rattus norvegicus
AC241717.1
Rattus norvegicus
AC242583.1
Rattus norvegicus
AC241930.1
Rattus norvegicus
AC242273.1
Rattus norvegicus
AC242259.1
Saccharomyces cerevisiae
GRX2
Saccharomyces cerevisiae
GRX1

In other databases

CellAge gene expression
  • This gene is present as GLRX

GPX1

1.
Identifier
rs1800668
Cytogenetic Location
3p21.31
UCSC Genome Browser
View 3p21.31 on the UCSC genome browser

Gene details

HGNC symbol
GPX1
Aliases
GPXD; GSHPX1 
Common name
glutathione peroxidase 1 
Description
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants and multiple pseudogenes of this gene have been identified. [provided by RefSeq, Jul 2016]
Other longevity studies of this gene
1
OMIM
138320
Ensembl
ENSG00000233276
UniProt/Swiss-Prot
GPX1_HUMAN
Entrez Gene
2876
UniGene
76686
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
gpx-4
Caenorhabditis elegans
gpx-5
Caenorhabditis elegans
gpx-3
Mus musculus
Gpx1
Rattus norvegicus
Gpx1
Saccharomyces cerevisiae
HYR1
Saccharomyces cerevisiae
GPX1

In other databases

GenAge human genes
  • This gene is present as GPX1

GPX3

1.
Identifier
rs1946234
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
2.
Identifier
rs2042236
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
3.
Identifier
rs2070593
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
4.
Identifier
rs3792798
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
5.
Identifier
rs3805435
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
6.
Identifier
rs4958434
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
7.
Identifier
rs4958872
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
8.
Identifier
rs8177431
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
9.
Identifier
rs870407
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser

Gene details

HGNC symbol
GPX3
Aliases
GPx-P; GSHPx-3; GSHPx-P 
Common name
glutathione peroxidase 3 
Description
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Other longevity studies of this gene
8
OMIM
138321
Ensembl
ENSG00000211445
UniProt/Swiss-Prot
GPX3_HUMAN
Entrez Gene
2878
UniGene
386793
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
gpx-4
Caenorhabditis elegans
gpx-5
Caenorhabditis elegans
gpx-3
Danio rerio
gpx3
Mus musculus
Gpx3
Rattus norvegicus
Gpx3
Saccharomyces cerevisiae
HYR1
Saccharomyces cerevisiae
GPX1

In other databases

GenAge microarray genes
  • This gene is present as GPX3

GPX4

1.
Identifier
rs3746165
Cytogenetic Location
19p13.3
UCSC Genome Browser
View 19p13.3 on the UCSC genome browser
2.
Identifier
rs4588110
Cytogenetic Location
19p13.3
UCSC Genome Browser
View 19p13.3 on the UCSC genome browser
3.
Identifier
rs4807542
Cytogenetic Location
19p13.3
UCSC Genome Browser
View 19p13.3 on the UCSC genome browser
4.
Identifier
rs8178977
Cytogenetic Location
19p13.3
UCSC Genome Browser
View 19p13.3 on the UCSC genome browser

Gene details

HGNC symbol
GPX4
Aliases
MCSP; SMDS; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx 
Common name
glutathione peroxidase 4 
Description
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
Other longevity studies of this gene
3
OMIM
138322
Ensembl
ENSG00000167468
UniProt/Swiss-Prot
GPX4_HUMAN
Entrez Gene
2879
UniGene
433951
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
gpx4b
Danio rerio
gpx4a
Mus musculus
Gpx4
Rattus norvegicus
Gpx4
Saccharomyces cerevisiae
HYR1
Saccharomyces cerevisiae
GPX1
Schizosaccharomyces pombe
gpx1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Gpx4
GenAge human genes
  • This gene is present as GPX4

GSR

1.
Identifier
rs3779647
Cytogenetic Location
8p12
UCSC Genome Browser
View 8p12 on the UCSC genome browser
2.
Identifier
rs8190893
Cytogenetic Location
8p12
UCSC Genome Browser
View 8p12 on the UCSC genome browser
3.
Identifier
rs8190996
Cytogenetic Location
8p12
UCSC Genome Browser
View 8p12 on the UCSC genome browser
4.
Identifier
rs1002149
In Other Studies (IDs)
259
Cytogenetic Location
8p12
UCSC Genome Browser
View 8p12 on the UCSC genome browser
5.
Identifier
rs17557435
Cytogenetic Location
8p12
UCSC Genome Browser
View 8p12 on the UCSC genome browser
6.
Identifier
rs2253409
Cytogenetic Location
8p12
UCSC Genome Browser
View 8p12 on the UCSC genome browser
7.
Identifier
rs2978663
Cytogenetic Location
8p12
UCSC Genome Browser
View 8p12 on the UCSC genome browser
8.
Identifier
rs3594
Cytogenetic Location
8p12
UCSC Genome Browser
View 8p12 on the UCSC genome browser

Gene details

HGNC symbol
GSR
Aliases
HEL-75; HEL-S-122m 
Common name
glutathione-disulfide reductase 
Description
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Other longevity studies of this gene
8
OMIM
138300
Ensembl
ENSG00000104687
UniProt/Swiss-Prot
GSHR_HUMAN
Entrez Gene
2936
UniGene
271510
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
gsr-1
Danio rerio
gsr
Mus musculus
Gsr
Rattus norvegicus
Gsr
Saccharomyces cerevisiae
GLR1
Schizosaccharomyces pombe
pgr1

In other databases

GenAge human genes
  • This gene is present as GSR

GSS

1.
Identifier
rs17309872
Cytogenetic Location
20q11.22
UCSC Genome Browser
View 20q11.22 on the UCSC genome browser
2.
Identifier
rs17310467
Cytogenetic Location
20q11.22
UCSC Genome Browser
View 20q11.22 on the UCSC genome browser
3.
Identifier
rs2236270
Cytogenetic Location
20q11.22
UCSC Genome Browser
View 20q11.22 on the UCSC genome browser
4.
Identifier
rs6088659
Cytogenetic Location
20q11.22
UCSC Genome Browser
View 20q11.22 on the UCSC genome browser
5.
Identifier
rs6088660
Cytogenetic Location
20q11.22
UCSC Genome Browser
View 20q11.22 on the UCSC genome browser
6.
Identifier
rs725521
Cytogenetic Location
20q11.22
UCSC Genome Browser
View 20q11.22 on the UCSC genome browser
7.
Identifier
rs7265992
Cytogenetic Location
20q11.22
UCSC Genome Browser
View 20q11.22 on the UCSC genome browser

Gene details

HGNC symbol
GSS
Aliases
GSHS; HEL-S-64p; HEL-S-88n 
Common name
glutathione synthetase 
Description
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
6
OMIM
601002
Ensembl
ENSG00000100983
UniProt/Swiss-Prot
GSHB_HUMAN
Entrez Gene
2937
UniGene
82327
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
gss-1
Danio rerio
gss
Drosophila melanogaster
CG32495
Drosophila melanogaster
GS
Drosophila melanogaster
GS
Drosophila melanogaster
CG32495
Mus musculus
Gss
Rattus norvegicus
Gss
Saccharomyces cerevisiae
GSH2
Schizosaccharomyces pombe
gsa1

In other databases

GenAge human genes
  • This gene is present as GSS

GSTM3

1.
Identifier
rs10735234
Cytogenetic Location
1p13.3
UCSC Genome Browser
View 1p13.3 on the UCSC genome browser
2.
Identifier
rs1537236
Cytogenetic Location
1p13.3
UCSC Genome Browser
View 1p13.3 on the UCSC genome browser
3.
Identifier
rs7483
Cytogenetic Location
1p13.3
UCSC Genome Browser
View 1p13.3 on the UCSC genome browser

Gene details

HGNC symbol
GSTM3
Aliases
GST5; GSTB; GTM3; GSTM3-3 
Common name
glutathione S-transferase mu 3 
Description
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Other longevity studies of this gene
2
OMIM
138390
Ensembl
ENSG00000134202
UniProt/Swiss-Prot
GSTM3_HUMAN
Entrez Gene
2947
UniGene
2006
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
gst-23
Caenorhabditis elegans
gst-41
Caenorhabditis elegans
gst-1
Caenorhabditis elegans
gst-25
Danio rerio
gstm.2
Danio rerio
gstm.3
Danio rerio
gstm.1
Mus musculus
Gstm5
Rattus norvegicus
NEWGENE_620381
Rattus norvegicus
NEWGENE_620381
Rattus norvegicus
Gstm5

GSTP1

1.
Identifier
rs1138272
Cytogenetic Location
11q13.2
UCSC Genome Browser
View 11q13.2 on the UCSC genome browser
2.
Identifier
rs1695
Cytogenetic Location
11q13.2
UCSC Genome Browser
View 11q13.2 on the UCSC genome browser
3.
Identifier
rs7927381
Cytogenetic Location
11q13.2
UCSC Genome Browser
View 11q13.2 on the UCSC genome browser
4.
Identifier
rs7941395
Cytogenetic Location
11q13.2
UCSC Genome Browser
View 11q13.2 on the UCSC genome browser

Gene details

HGNC symbol
GSTP1
Aliases
PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22 
Common name
glutathione S-transferase pi 1 
Description
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
4
OMIM
134660
Ensembl
ENSG00000084207
UniProt/Swiss-Prot
GSTP1_HUMAN
Entrez Gene
2950
UniGene
523836
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
gst-23
Caenorhabditis elegans
gst-25
Caenorhabditis elegans
gst-41
Caenorhabditis elegans
gst-1
Danio rerio
gstp2
Danio rerio
gstp1
Mus musculus
Gstp1
Mus musculus
Gstp2
Rattus norvegicus
Gstp1

In other databases

GenAge human genes
  • This gene is present as GSTP1
GenAge microarray genes
  • This gene is present as GSTP1

LOC105372352

1.
Identifier
rs759628
Cytogenetic Location
19q12
UCSC Genome Browser
View 19q12 on the UCSC genome browser

Gene details

HGNC symbol
LOC105372352
Aliases
CTB-32O4.2; CTB-32O4.3; CTB-32O4.4 
Common name
uncharacterized LOC105372352 
Description
OMIM
Ensembl
ENSG00000267498
UniProt/Swiss-Prot
Entrez Gene
105372352
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC105376622

1.
Identifier
rs208682
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
2.
Identifier
rs2266630
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
3.
Identifier
rs554518
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser

Gene details

HGNC symbol
LOC105376622
Aliases
 
Common name
uncharacterized LOC105376622 
Description
Other longevity studies of this gene
2
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105376622
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC105378228

1.
Identifier
rs2042235
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser
2.
Identifier
rs3763015
Cytogenetic Location
5q33.1
UCSC Genome Browser
View 5q33.1 on the UCSC genome browser

Gene details

HGNC symbol
LOC105378228
Aliases
 
Common name
uncharacterized LOC105378228 
Description
Other longevity studies of this gene
1
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105378228
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOX

1.
Identifier
rs17352686
Cytogenetic Location
5q23.1
UCSC Genome Browser
View 5q23.1 on the UCSC genome browser

Gene details

HGNC symbol
LOX
Aliases
AAT10 
Common name
lysyl oxidase 
Description
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
OMIM
153455
Ensembl
ENSG00000113083
UniProt/Swiss-Prot
B0AZT2_HUMAN
Entrez Gene
4015
UniGene
102267
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
LOX (1 of many)
Danio rerio
loxa
Drosophila melanogaster
lox
Mus musculus
Lox
Rattus norvegicus
Lox

In other databases

CellAge
  • This gene is present as LOX
CellAge gene expression
  • This gene is present as LOX

MT1A

1.
Identifier
rs4784701
Cytogenetic Location
16q13
UCSC Genome Browser
View 16q13 on the UCSC genome browser
2.
Identifier
rs8049883
Cytogenetic Location
16q13
UCSC Genome Browser
View 16q13 on the UCSC genome browser

Gene details

HGNC symbol
MT1A
Aliases
MT1; MTC; MT1S 
Common name
metallothionein 1A 
Description
Other longevity studies of this gene
2
OMIM
156350
Ensembl
ENSG00000205362
UniProt/Swiss-Prot
MT1A_HUMAN
Entrez Gene
4489
UniGene
655199
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Mt2
Rattus norvegicus
Mt1m
Rattus norvegicus
Mt2A

In other databases

GenAge microarray genes
  • This gene is present as MT1A
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Mt2

MYH7B

1.
Identifier
rs6088662
Cytogenetic Location
20q11.22
UCSC Genome Browser
View 20q11.22 on the UCSC genome browser

Gene details

HGNC symbol
MYH7B
Aliases
MHC14; MYH14 
Common name
myosin heavy chain 7B 
Description
The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]
OMIM
609928
Ensembl
ENSG00000078814
UniProt/Swiss-Prot
MYH7B_HUMAN
Entrez Gene
57644
UniGene
414122
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
myo-5
Caenorhabditis elegans
unc-54
Caenorhabditis elegans
myo-6
Caenorhabditis elegans
myo-3
Caenorhabditis elegans
myo-1
Danio rerio
myh7bb
Danio rerio
myh7ba
Drosophila melanogaster
Mhc
Mus musculus
Myh7b
Rattus norvegicus
Myh7b
Saccharomyces cerevisiae
MYO1

NDUFV1

1.
Identifier
rs12793832
Cytogenetic Location
11q13.2
UCSC Genome Browser
View 11q13.2 on the UCSC genome browser

Gene details

HGNC symbol
NDUFV1
Aliases
UQOR1; CI-51K; CI51KD 
Common name
NADH:ubiquinone oxidoreductase core subunit V1 
Description
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
OMIM
161015
Ensembl
ENSG00000167792
UniProt/Swiss-Prot
E5KNH5_HUMAN
Entrez Gene
4723
UniGene
7744
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
nuo-1
Danio rerio
ndufv1
Drosophila melanogaster
CG11423
Drosophila melanogaster
CG8102
Drosophila melanogaster
CG9140
Mus musculus
Ndufv1
Rattus norvegicus
Ndufv1
Schizosaccharomyces pombe
SPBC18E5.10

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as nuo-1

NDUFV2

1.
Identifier
rs1039825
Cytogenetic Location
18p11.22
UCSC Genome Browser
View 18p11.22 on the UCSC genome browser
2.
Identifier
rs11872481
Cytogenetic Location
18p11.22
UCSC Genome Browser
View 18p11.22 on the UCSC genome browser
3.
Identifier
rs17413344
Cytogenetic Location
18p11.22
UCSC Genome Browser
View 18p11.22 on the UCSC genome browser
4.
Identifier
rs4148965
Cytogenetic Location
18p11.22
UCSC Genome Browser
View 18p11.22 on the UCSC genome browser
5.
Identifier
rs4148966
Cytogenetic Location
18p11.22
UCSC Genome Browser
View 18p11.22 on the UCSC genome browser
6.
Identifier
rs906807
Cytogenetic Location
18p11.22
UCSC Genome Browser
View 18p11.22 on the UCSC genome browser
7.
Identifier
rs977581
Cytogenetic Location
18p11.22
UCSC Genome Browser
View 18p11.22 on the UCSC genome browser

Gene details

HGNC symbol
NDUFV2
Aliases
CI-24k 
Common name
NADH:ubiquinone oxidoreductase core subunit V2 
Description
The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]
Other longevity studies of this gene
6
OMIM
600532
Ensembl
ENSG00000178127
UniProt/Swiss-Prot
NDUV2_HUMAN
Entrez Gene
4729
UniGene
464572
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
F53F4.10
Danio rerio
ndufv2
Drosophila melanogaster
CG5703
Drosophila melanogaster
CG6485
Mus musculus
Ndufv2
Rattus norvegicus
Ndufv2
Schizosaccharomyces pombe
SPAC11E3.12

NOS3

1.
Identifier
rs12703107
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
2.
Identifier
rs1541861
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
3.
Identifier
rs1799983
In Other Studies (IDs)
1870
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
4.
Identifier
rs1800779
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
5.
Identifier
rs1808593
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
6.
Identifier
rs2853792
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
7.
Identifier
rs3793342
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
8.
Identifier
rs3918186
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
9.
Identifier
rs3918188rs3918226
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
10.
Identifier
rs3918227
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
11.
Identifier
rs743506
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser
12.
Identifier
rs7830
Cytogenetic Location
7q36.1
UCSC Genome Browser
View 7q36.1 on the UCSC genome browser

Gene details

HGNC symbol
NOS3
Aliases
eNOS; ECNOS 
Common name
nitric oxide synthase 3 
Description
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Other longevity studies of this gene
13
OMIM
163729
Ensembl
ENSG00000164867
UniProt/Swiss-Prot
A0A0A0MTA6_HUMAN
Entrez Gene
4846
UniGene
647092
HapMap
View on HapMap

Homologs in model organisms

Drosophila melanogaster
Nos
Mus musculus
Nos3
Rattus norvegicus
Nos3
Saccharomyces cerevisiae
NCP1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Nos3

NOX1

1.
Identifier
rs10126566
Cytogenetic Location
Xq22.1
UCSC Genome Browser
View Xq22.1 on the UCSC genome browser
2.
Identifier
rs12156942
Cytogenetic Location
Xq22.1
UCSC Genome Browser
View Xq22.1 on the UCSC genome browser
3.
Identifier
rs16983650
Cytogenetic Location
Xq22.1
UCSC Genome Browser
View Xq22.1 on the UCSC genome browser
4.
Identifier
rs4828068
Cytogenetic Location
Xq22.1
UCSC Genome Browser
View Xq22.1 on the UCSC genome browser
5.
Identifier
rs4828071
Cytogenetic Location
Xq22.1
UCSC Genome Browser
View Xq22.1 on the UCSC genome browser
6.
Identifier
rs5921669
Cytogenetic Location
Xq22.1
UCSC Genome Browser
View Xq22.1 on the UCSC genome browser
7.
Identifier
rs5921682
Cytogenetic Location
Xq22.1
UCSC Genome Browser
View Xq22.1 on the UCSC genome browser
8.
Identifier
rs6620949
Cytogenetic Location
Xq22.1
UCSC Genome Browser
View Xq22.1 on the UCSC genome browser

Gene details

HGNC symbol
NOX1
Aliases
MOX1; NOH1; NOH-1; GP91-2 
Common name
NADPH oxidase 1 
Description
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Other longevity studies of this gene
7
OMIM
300225
Ensembl
ENSG00000007952
UniProt/Swiss-Prot
A6NGA6_HUMAN
Entrez Gene
27035
UniGene
592227
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
nox1
Mus musculus
Nox1
Rattus norvegicus
Nox1

In other databases

CellAge
  • This gene is present as NOX1

PARK7

1.
Identifier
rs161802
Cytogenetic Location
1p36.23
UCSC Genome Browser
View 1p36.23 on the UCSC genome browser
2.
Identifier
rs178932
Cytogenetic Location
1p36.23
UCSC Genome Browser
View 1p36.23 on the UCSC genome browser
3.
Identifier
rs225092
Cytogenetic Location
1p36.23
UCSC Genome Browser
View 1p36.23 on the UCSC genome browser
4.
Identifier
rs225119
Cytogenetic Location
1p36.23
UCSC Genome Browser
View 1p36.23 on the UCSC genome browser
5.
Identifier
rs226242
Cytogenetic Location
1p36.23
UCSC Genome Browser
View 1p36.23 on the UCSC genome browser
6.
Identifier
rs226258
Cytogenetic Location
1p36.23
UCSC Genome Browser
View 1p36.23 on the UCSC genome browser
7.
Identifier
rs4908488
Cytogenetic Location
1p36.23
UCSC Genome Browser
View 1p36.23 on the UCSC genome browser

Gene details

HGNC symbol
PARK7
Aliases
DJ1; DJ-1; GATD2; HEL-S-67p 
Common name
Parkinsonism associated deglycase 
Description
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
6
OMIM
602533
Ensembl
ENSG00000116288
UniProt/Swiss-Prot
PARK7_HUMAN
Entrez Gene
11315
UniGene
419640
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
djr-1.1
Caenorhabditis elegans
djr-1.2
Danio rerio
park7
Drosophila melanogaster
DJ-1alpha
Drosophila melanogaster
dj-1beta
Mus musculus
Park7
Rattus norvegicus
Park7
Schizosaccharomyces pombe
SPAC22E12.03c

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as DJ-1alpha
CellAge
  • This gene is present as PARK7

PON1

1.
Identifier
rs17166818
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
2.
Identifier
rs2049649
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
3.
Identifier
rs2074351
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
4.
Identifier
rs2237583
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
5.
Identifier
rs2237584
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
6.
Identifier
rs2272365
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
7.
Identifier
rs2299257
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
8.
Identifier
rs2299261
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
9.
Identifier
rs2299262
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
10.
Identifier
rs3735590
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
11.
Identifier
rs3917521
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
12.
Identifier
rs3917550
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
13.
Identifier
rs3917556
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
14.
Identifier
rs662
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
15.
Identifier
rs757158
In Other Studies (IDs)
2096
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
16.
Identifier
rs854551
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
17.
Identifier
rs854552
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
18.
Identifier
rs854555
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
19.
Identifier
rs854565
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
20.
Identifier
rs854567
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
21.
Identifier
rs854568
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
22.
Identifier
rs854569
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
23.
Identifier
rs854570
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
24.
Identifier
rs854573
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser

Gene details

HGNC symbol
PON1
Aliases
ESA; PON; MVCD5 
Common name
paraoxonase 1 
Description
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
Other longevity studies of this gene
31
OMIM
168820
Ensembl
ENSG00000005421
UniProt/Swiss-Prot
PON1_HUMAN
Entrez Gene
5444
UniGene
370995
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
poml-4
Caenorhabditis elegans
mec-6
Caenorhabditis elegans
poml-2
Caenorhabditis elegans
poml-3
Danio rerio
pon3.2
Danio rerio
pon3.2
Danio rerio
pon2
Danio rerio
pon1
Mus musculus
Pon1
Rattus norvegicus
Pon1

In other databases

GenAge human genes
  • This gene is present as PON1
CellAge
  • This gene is present as PON1

PON2

1.
Identifier
rs10487133
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
2.
Identifier
rs12026
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
3.
Identifier
rs12669182
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
4.
Identifier
rs2299267
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
5.
Identifier
rs2375005
In Other Studies (IDs)
2101
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
6.
Identifier
rs43037
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
7.
Identifier
rs4729189
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
8.
Identifier
rs730365
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
9.
Identifier
rs7493
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
10.
Identifier
rs7802018
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
11.
Identifier
rs7803148
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser

Gene details

HGNC symbol
PON2
Aliases
 
Common name
paraoxonase 2 
Description
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
14
OMIM
602447
Ensembl
ENSG00000105854
UniProt/Swiss-Prot
A0A0J9YYG4_HUMAN
Entrez Gene
5445
UniGene
514420
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
poml-2
Caenorhabditis elegans
poml-4
Caenorhabditis elegans
poml-3
Caenorhabditis elegans
mec-6
Danio rerio
pon3.2
Danio rerio
pon3.2
Danio rerio
pon2
Danio rerio
pon1
Mus musculus
Pon2
Rattus norvegicus
Pon2

In other databases

GenAge microarray genes
  • This gene is present as PON2

PON3

1.
Identifier
rs17879277
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
2.
Identifier
rs10487132
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
3.
Identifier
rs11767787
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
4.
Identifier
rs12534317
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
5.
Identifier
rs2057682
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
6.
Identifier
rs2072200
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser
7.
Identifier
rs978903
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser

Gene details

HGNC symbol
PON3
Aliases
 
Common name
paraoxonase 3 
Description
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
6
OMIM
602720
Ensembl
ENSG00000105852
UniProt/Swiss-Prot
PON3_HUMAN
Entrez Gene
5446
UniGene
440967
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
poml-2
Caenorhabditis elegans
poml-4
Caenorhabditis elegans
poml-3
Caenorhabditis elegans
mec-6
Danio rerio
pon3.2
Danio rerio
pon3.2
Danio rerio
pon2
Danio rerio
pon1
Mus musculus
Pon3
Rattus norvegicus
Pon3

PPP1R9A

1.
Identifier
rs2374983
In Other Studies (IDs)
1398 1449
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser

Gene details

HGNC symbol
PPP1R9A
Aliases
NRB1; NRBI; Neurabin-I 
Common name
protein phosphatase 1 regulatory subunit 9A 
Description
This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Other longevity studies of this gene
5
OMIM
602468
Ensembl
ENSG00000158528
UniProt/Swiss-Prot
A4D1I0_HUMAN
Entrez Gene
55607
UniGene
21816
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
nab-1
Danio rerio
ppp1r9a
Drosophila melanogaster
Spn
Mus musculus
Ppp1r9a
Rattus norvegicus
Ppp1r9a

PRDX3

1.
Identifier
rs11198811
Cytogenetic Location
10q26.11
UCSC Genome Browser
View 10q26.11 on the UCSC genome browser
2.
Identifier
rs1553850
Cytogenetic Location
10q26.11
UCSC Genome Browser
View 10q26.11 on the UCSC genome browser
3.
Identifier
rs3377
Cytogenetic Location
10q26.11
UCSC Genome Browser
View 10q26.11 on the UCSC genome browser
4.
Identifier
rs3740562
Cytogenetic Location
10q26.11
UCSC Genome Browser
View 10q26.11 on the UCSC genome browser
5.
Identifier
rs4752257
Cytogenetic Location
10q26.11
UCSC Genome Browser
View 10q26.11 on the UCSC genome browser
6.
Identifier
rs7768
Cytogenetic Location
10q26.11
UCSC Genome Browser
View 10q26.11 on the UCSC genome browser

Gene details

HGNC symbol
PRDX3
Aliases
AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III 
Common name
peroxiredoxin 3 
Description
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
Other longevity studies of this gene
5
OMIM
604769
Ensembl
ENSG00000165672
UniProt/Swiss-Prot
PRDX3_HUMAN
Entrez Gene
10935
UniGene
523302
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
prdx-3
Danio rerio
prdx3
Drosophila melanogaster
Prx3
Mus musculus
Prdx3
Rattus norvegicus
Prdx3
Saccharomyces cerevisiae
TSA1
Saccharomyces cerevisiae
TSA2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as prdx-3
  • A homolog of this gene for Saccharomyces cerevisiae is present as TSA1
GenAge microarray genes
  • This gene is present as PRDX3
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as TSA1

SOD1

1.
Identifier
rs1041740
In Other Studies (IDs)
2142
Cytogenetic Location
21q22.11
UCSC Genome Browser
View 21q22.11 on the UCSC genome browser
2.
Identifier
rs2070424
In Other Studies (IDs)
2137
Cytogenetic Location
21q22.11
UCSC Genome Browser
View 21q22.11 on the UCSC genome browser
3.
Identifier
rs4998557
In Other Studies (IDs)
2134 2686
Cytogenetic Location
21q22.11
UCSC Genome Browser
View 21q22.11 on the UCSC genome browser

Gene details

HGNC symbol
SOD1
Aliases
ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer 
Common name
superoxide dismutase 1 
Description
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
7
OMIM
147450
Ensembl
ENSG00000142168
UniProt/Swiss-Prot
SODC_HUMAN
Entrez Gene
6647
UniGene
443914
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
sod-4
Danio rerio
sod1
Drosophila melanogaster
Sod
Mus musculus
Sod1
Rattus norvegicus
Sod1
Saccharomyces cerevisiae
SOD1
Schizosaccharomyces pombe
sod1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
  • A homolog of this gene for Drosophila melanogaster is present as Sod
GenAge human genes
  • This gene is present as SOD1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
CellAge
  • This gene is present as SOD1

SOD3

1.
Identifier
rs17878863
Cytogenetic Location
4p15.2
UCSC Genome Browser
View 4p15.2 on the UCSC genome browser
2.
Identifier
rs2284659
In Other Studies (IDs)
2702
Cytogenetic Location
4p15.2
UCSC Genome Browser
View 4p15.2 on the UCSC genome browser
3.
Identifier
rs2855262
In Other Studies (IDs)
2699
Cytogenetic Location
4p15.2
UCSC Genome Browser
View 4p15.2 on the UCSC genome browser
4.
Identifier
rs699473
In Other Studies (IDs)
2150
Cytogenetic Location
4p15.2
UCSC Genome Browser
View 4p15.2 on the UCSC genome browser
5.
Identifier
rs800442
Cytogenetic Location
4p15.2
UCSC Genome Browser
View 4p15.2 on the UCSC genome browser
6.
Identifier
rs8192287
In Other Studies (IDs)
2146
Cytogenetic Location
4p15.2
UCSC Genome Browser
View 4p15.2 on the UCSC genome browser

Gene details

HGNC symbol
SOD3
Aliases
EC-SOD 
Common name
superoxide dismutase 3 
Description
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
Other longevity studies of this gene
16
OMIM
185490
Ensembl
ENSG00000109610
UniProt/Swiss-Prot
A0A140VJU8_HUMAN
Entrez Gene
6649
UniGene
2420
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
sod3b
Drosophila melanogaster
Sod3
Mus musculus
Sod3
Rattus norvegicus
Sod3
Saccharomyces cerevisiae
SOD1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
  • A homolog of this gene for Mus musculus is present as SOD3
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1

SRXN1

1.
Identifier
rs2008022
Cytogenetic Location
20p13
UCSC Genome Browser
View 20p13 on the UCSC genome browser
2.
Identifier
rs6053666
Cytogenetic Location
20p13
UCSC Genome Browser
View 20p13 on the UCSC genome browser
3.
Identifier
rs6085283
Cytogenetic Location
20p13
UCSC Genome Browser
View 20p13 on the UCSC genome browser
4.
Identifier
rs6107696
Cytogenetic Location
20p13
UCSC Genome Browser
View 20p13 on the UCSC genome browser
5.
Identifier
rs7269823
Cytogenetic Location
20p13
UCSC Genome Browser
View 20p13 on the UCSC genome browser

Gene details

HGNC symbol
SRXN1
Aliases
SRX; Npn3; SRX1; C20orf139 
Common name
sulfiredoxin 1 
Description
Other longevity studies of this gene
4
OMIM
Ensembl
ENSG00000271303
UniProt/Swiss-Prot
SRXN1_HUMAN
Entrez Gene
140809
UniGene
516830
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
srxn1
Drosophila melanogaster
CG6762
Mus musculus
Srxn1
Rattus norvegicus
Srxn1
Saccharomyces cerevisiae
SRX1
Schizosaccharomyces pombe
srx1

In other databases

GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SRX1

TXN2

1.
Identifier
rs12159295
Cytogenetic Location
22q12.3
UCSC Genome Browser
View 22q12.3 on the UCSC genome browser
2.
Identifier
rs139998
Cytogenetic Location
22q12.3
UCSC Genome Browser
View 22q12.3 on the UCSC genome browser
3.
Identifier
rs2267337
Cytogenetic Location
22q12.3
UCSC Genome Browser
View 22q12.3 on the UCSC genome browser
4.
Identifier
rs5756202
Cytogenetic Location
22q12.3
UCSC Genome Browser
View 22q12.3 on the UCSC genome browser
5.
Identifier
rs7284468
Cytogenetic Location
22q12.3
UCSC Genome Browser
View 22q12.3 on the UCSC genome browser
6.
Identifier
rs8139906
Cytogenetic Location
22q12.3
UCSC Genome Browser
View 22q12.3 on the UCSC genome browser
7.
Identifier
rs9619607
Cytogenetic Location
22q12.3
UCSC Genome Browser
View 22q12.3 on the UCSC genome browser

Gene details

HGNC symbol
TXN2
Aliases
TXN; MTRX; TRX2; MT-TRX; COXPD29 
Common name
thioredoxin 2 
Description
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
6
OMIM
609063
Ensembl
ENSG00000100348
UniProt/Swiss-Prot
B4DX69_HUMAN
Entrez Gene
25828
UniGene
211929
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
trx-2
Danio rerio
txn2
Drosophila melanogaster
CG8517
Drosophila melanogaster
CG3719
Drosophila melanogaster
CG8993
Mus musculus
Txn2
Rattus norvegicus
Txn2

UCP1

1.
Identifier
rs12502572
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
2.
Identifier
rs1472268
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
3.
Identifier
rs1800592
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
4.
Identifier
rs1800661
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
5.
Identifier
rs2071416
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
6.
Identifier
rs3811790
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
7.
Identifier
rs6536991
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
8.
Identifier
rs6822807
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
9.
Identifier
rs7687015
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser
10.
Identifier
rs7688743
Cytogenetic Location
4q31.1
UCSC Genome Browser
View 4q31.1 on the UCSC genome browser

Gene details

HGNC symbol
UCP1
Aliases
UCP; SLC25A7 
Common name
uncoupling protein 1 
Description
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
11
OMIM
113730
Ensembl
ENSG00000109424
UniProt/Swiss-Prot
Q4KMT7_HUMAN
Entrez Gene
7350
UniGene
249211
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
ucp1
Mus musculus
Ucp1
Rattus norvegicus
Ucp1
Rattus norvegicus
LOC100909612
Saccharomyces cerevisiae
DIC1

In other databases

GenAge human genes
  • This gene is present as UCP1

UCP2

1.
Identifier
rs659366
In Other Studies (IDs)
1689
Cytogenetic Location
11q13.4
UCSC Genome Browser
View 11q13.4 on the UCSC genome browser
2.
Identifier
rs7109266
Cytogenetic Location
11q13.4
UCSC Genome Browser
View 11q13.4 on the UCSC genome browser
3.
Identifier
rs2632725
Cytogenetic Location
11q13.4
UCSC Genome Browser
View 11q13.4 on the UCSC genome browser
4.
Identifier
rs591758
Cytogenetic Location
11q13.4
UCSC Genome Browser
View 11q13.4 on the UCSC genome browser

Gene details

HGNC symbol
UCP2
Aliases
UCPH; BMIQ4; SLC25A8 
Common name
uncoupling protein 2 
Description
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
7
OMIM
601693
Ensembl
ENSG00000175567
UniProt/Swiss-Prot
A0A024R5N5_HUMAN
Entrez Gene
7351
UniGene
80658
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
ucp2
Mus musculus
Ucp2
Rattus norvegicus
Ucp2
Saccharomyces cerevisiae
DIC1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as UCP2
  • A homolog of this gene for Mus musculus is present as Ucp2
GenAge human genes
  • This gene is present as UCP2
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as ucp2

UQCRFS1

1.
Identifier
rs10420904
Cytogenetic Location
19q12
UCSC Genome Browser
View 19q12 on the UCSC genome browser
2.
Identifier
rs3760841
Cytogenetic Location
19q12
UCSC Genome Browser
View 19q12 on the UCSC genome browser
3.
Identifier
rs8109749
Cytogenetic Location
19q12
UCSC Genome Browser
View 19q12 on the UCSC genome browser

Gene details

HGNC symbol
UQCRFS1
Aliases
RIP1; RIS1; RISP; UQCR5 
Common name
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 
Description
Other longevity studies of this gene
2
OMIM
191327
Ensembl
ENSG00000169021
UniProt/Swiss-Prot
UCRI_HUMAN
Entrez Gene
7386
UniGene
743307
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
isp-1
Danio rerio
uqcrfs1
Drosophila melanogaster
RFeSP
Mus musculus
Uqcrfs1
Rattus norvegicus
Uqcrfs1
Saccharomyces cerevisiae
RIP1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as isp-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as RIP1
GenAge microarray genes

XDH

1.
Identifier
rs1042039
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
2.
Identifier
rs11904439
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
3.
Identifier
rs1366811
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
4.
Identifier
rs1429372
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
5.
Identifier
rs169596
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
6.
Identifier
rs17038412
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
7.
Identifier
rs2043013
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
8.
Identifier
rs206812
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
9.
Identifier
rs206849
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
10.
Identifier
rs206851
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
11.
Identifier
rs206860
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
12.
Identifier
rs2073316
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
13.
Identifier
rs207444
In Other Studies (IDs)
270
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
14.
Identifier
rs207455
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
15.
Identifier
rs2163059
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
16.
Identifier
rs2281547
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
17.
Identifier
rs494852
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
18.
Identifier
rs6543626
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
19.
Identifier
rs6718606
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
20.
Identifier
rs7574920
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
21.
Identifier
rs761926
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser
22.
Identifier
rs994727
Cytogenetic Location
2p23.1
UCSC Genome Browser
View 2p23.1 on the UCSC genome browser

Gene details

HGNC symbol
XDH
Aliases
XO; XOR; XAN1 
Common name
xanthine dehydrogenase 
Description
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
Other longevity studies of this gene
23
OMIM
607633
Ensembl
ENSG00000158125
UniProt/Swiss-Prot
XDH_HUMAN
Entrez Gene
7498
UniGene
250
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
F55B11.1
Caenorhabditis elegans
gad-3
Caenorhabditis elegans
F15E6.6
Danio rerio
xdh
Drosophila melanogaster
AOX4
Drosophila melanogaster
ry
Drosophila melanogaster
AOX1
Drosophila melanogaster
AOX2
Drosophila melanogaster
AOX3
Mus musculus
Xdh
Rattus norvegicus
Xdh

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as F55B11.1
  • A homolog of this gene for Drosophila melanogaster is present as ry

References

Dato et al. (2014)

Other variants which are also part of this study