LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
Variants (282)
- Gene summary:
- No gene (2)
- ACOX1 (10)
- AOX1 (24)
- CAT (11)
- CP (12)
- CYC1 (2)
- CYP1B1 (7)
- G6PD (2)
- GCLC (14)
- GLRX (8)
- GPX1 (1)
- GPX3 (9)
- GPX4 (4)
- GSR (8)
- GSS (7)
- GSTM3 (3)
- GSTP1 (4)
- LOC105372352 (1)
- LOC105376622 (3)
- LOC105378228 (2)
- LOX (1)
- MT1A (2)
- MYH7B (1)
- NDUFV1 (1)
- NDUFV2 (7)
- NOS3 (12)
- NOX1 (8)
- PARK7 (7)
- PON1 (24)
- PON2 (11)
- PON3 (7)
- PPP1R9A (1)
- PRDX3 (6)
- SOD1 (3)
- SOD3 (6)
- SRXN1 (5)
- TXN2 (7)
- UCP1 (10)
- UCP2 (4)
- UQCRFS1 (3)
- XDH (22)
No gene
ACOX1
Gene details
- HGNC symbol
- ACOX1
- Aliases
- ACOX; SCOX; PALMCOX
- Common name
- acyl-CoA oxidase 1
- Description
- The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 9
- OMIM
- 609751
- Ensembl
- ENSG00000161533
- UniProt/Swiss-Prot
- ACOX1_HUMAN
- Entrez Gene
- 51
- UniGene
- 464137
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- F08A8.4
- Caenorhabditis elegans
- acox-5
- Caenorhabditis elegans
- F59F4.1
- Caenorhabditis elegans
- acox-3
- Caenorhabditis elegans
- acox-2
- Caenorhabditis elegans
- acox-1
- Danio rerio
- acox1
- Drosophila melanogaster
- CG4586
- Drosophila melanogaster
- CG5009
- Drosophila melanogaster
- Acox57D-p
- Drosophila melanogaster
- Acox57D-d
- Mus musculus
- Acox1
- Rattus norvegicus
- Acox1
- Saccharomyces cerevisiae
- POX1
AOX1
Gene details
- HGNC symbol
- AOX1
- Aliases
- AO; AOH1
- Common name
- aldehyde oxidase 1
- Description
- Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 23
- OMIM
- 602841
- Ensembl
- ENSG00000138356
- UniProt/Swiss-Prot
- AOXA_HUMAN
- Entrez Gene
- 316
- UniGene
- 406238
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- F15E6.6
- Caenorhabditis elegans
- F55B11.1
- Caenorhabditis elegans
- gad-3
- Danio rerio
- aox5
- Drosophila melanogaster
- AOX4
- Drosophila melanogaster
- AOX1
- Drosophila melanogaster
- ry
- Drosophila melanogaster
- AOX2
- Drosophila melanogaster
- AOX3
- Mus musculus
- Aox1
- Rattus norvegicus
- Aox1
In other databases
CAT
Gene details
- HGNC symbol
- CAT
- Aliases
- Common name
- catalase
- Description
- This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 17
- OMIM
- 115500
- Ensembl
- ENSG00000121691
- UniProt/Swiss-Prot
- CATA_HUMAN
- Entrez Gene
- 847
- UniGene
- 502302
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- ctl-2
- Caenorhabditis elegans
- ctl-3
- Caenorhabditis elegans
- ctl-1
- Danio rerio
- cat
- Drosophila melanogaster
- Cat
- Drosophila melanogaster
- CG9314
- Mus musculus
- Cat
- Rattus norvegicus
- Cat
- Saccharomyces cerevisiae
- CTA1
- Schizosaccharomyces pombe
- cta1
In other databases
CP
Gene details
- HGNC symbol
- CP
- Aliases
- CP-2
- Common name
- ceruloplasmin
- Description
- The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
- Other longevity studies of this gene
- 11
- OMIM
- 117700
- Ensembl
- ENSG00000047457
- UniProt/Swiss-Prot
- A5PL27_HUMAN
- Entrez Gene
- 1356
- UniGene
- 558314
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as CP
CYC1
Gene details
- HGNC symbol
- CYC1
- Aliases
- UQCR4; MC3DN6
- Common name
- cytochrome c1
- Description
- This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
- Other longevity studies of this gene
- 1
- OMIM
- 123980
- Ensembl
- ENSG00000179091
- UniProt/Swiss-Prot
- CY1_HUMAN
- Entrez Gene
- 1537
- UniGene
- 289271
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- cyc-1
- Danio rerio
- cyc1
- Drosophila melanogaster
- CG4769
- Drosophila melanogaster
- CG14508
- Mus musculus
- Cyc1
- Rattus norvegicus
- Cyc1
- Saccharomyces cerevisiae
- CYT1
- Schizosaccharomyces pombe
- cyt1
In other databases
CYP1B1
Gene details
- HGNC symbol
- CYP1B1
- Aliases
- CP1B; ASGD6; GLC3A; CYPIB1; P4501B1
- Common name
- cytochrome P450 family 1 subfamily B member 1
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 601771
- Ensembl
- ENSG00000138061
- UniProt/Swiss-Prot
- CP1B1_HUMAN
- Entrez Gene
- 1545
- UniGene
- 154654
- HapMap
- View on HapMap
Homologs in model organisms
G6PD
Gene details
- HGNC symbol
- G6PD
- Aliases
- G6PD1
- Common name
- glucose-6-phosphate dehydrogenase
- Description
- This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 1
- OMIM
- 305900
- Ensembl
- ENSG00000160211
- UniProt/Swiss-Prot
- G6PD_HUMAN
- Entrez Gene
- 2539
- UniGene
- 461047
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gspd-1
- Danio rerio
- g6pd
- Drosophila melanogaster
- Zw
- Mus musculus
- G6pdx
- Mus musculus
- G6pd2
- Rattus norvegicus
- G6pd
- Saccharomyces cerevisiae
- ZWF1
- Schizosaccharomyces pombe
- zwf1
In other databases
GCLC
Gene details
- HGNC symbol
- GCLC
- Aliases
- GCL; GCS; GLCL; GLCLC
- Common name
- glutamate-cysteine ligase catalytic subunit
- Description
- Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
- Other longevity studies of this gene
- 13
- OMIM
- 606857
- Ensembl
- ENSG00000001084
- UniProt/Swiss-Prot
- E1CEI4_HUMAN
- Entrez Gene
- 2729
- UniGene
- 654465
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gcs-1
- Danio rerio
- gclc
- Drosophila melanogaster
- Gclc
- Mus musculus
- Gclc
- Rattus norvegicus
- Gclc
- Saccharomyces cerevisiae
- GSH1
- Schizosaccharomyces pombe
- gcs1
In other databases
GLRX
Gene details
- HGNC symbol
- GLRX
- Aliases
- GRX; GRX1
- Common name
- glutaredoxin
- Description
- This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
- Other longevity studies of this gene
- 7
- OMIM
- 600443
- Ensembl
- ENSG00000173221
- UniProt/Swiss-Prot
- A0A024RAM2_HUMAN
- Entrez Gene
- 2745
- UniGene
- 28988
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- glrx-10
- Danio rerio
- glrx
- Mus musculus
- Glrx
- Rattus norvegicus
- AC243283.1
- Rattus norvegicus
- AC242890.1
- Rattus norvegicus
- AC244836.1
- Rattus norvegicus
- Glrx
- Rattus norvegicus
- AC240814.1
- Rattus norvegicus
- LOC305806
- Rattus norvegicus
- AC242886.1
- Rattus norvegicus
- AC241705.1
- Rattus norvegicus
- AC241562.1
- Rattus norvegicus
- AC241244.1
- Rattus norvegicus
- AC242860.1
- Rattus norvegicus
- AC241717.1
- Rattus norvegicus
- AC242583.1
- Rattus norvegicus
- AC241930.1
- Rattus norvegicus
- AC242273.1
- Rattus norvegicus
- AC242259.1
- Saccharomyces cerevisiae
- GRX2
- Saccharomyces cerevisiae
- GRX1
In other databases
- CellAge gene expression
- This gene is present as GLRX
GPX1
Gene details
- HGNC symbol
- GPX1
- Aliases
- GPXD; GSHPX1
- Common name
- glutathione peroxidase 1
- Description
- The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants and multiple pseudogenes of this gene have been identified. [provided by RefSeq, Jul 2016]
- Other longevity studies of this gene
- 1
- OMIM
- 138320
- Ensembl
- ENSG00000233276
- UniProt/Swiss-Prot
- GPX1_HUMAN
- Entrez Gene
- 2876
- UniGene
- 76686
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gpx-4
- Caenorhabditis elegans
- gpx-5
- Caenorhabditis elegans
- gpx-3
- Mus musculus
- Gpx1
- Rattus norvegicus
- Gpx1
- Saccharomyces cerevisiae
- HYR1
- Saccharomyces cerevisiae
- GPX1
In other databases
- GenAge human genes
- This gene is present as GPX1
GPX3
Gene details
- HGNC symbol
- GPX3
- Aliases
- GPx-P; GSHPx-3; GSHPx-P
- Common name
- glutathione peroxidase 3
- Description
- The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
- Other longevity studies of this gene
- 8
- OMIM
- 138321
- Ensembl
- ENSG00000211445
- UniProt/Swiss-Prot
- GPX3_HUMAN
- Entrez Gene
- 2878
- UniGene
- 386793
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gpx-4
- Caenorhabditis elegans
- gpx-5
- Caenorhabditis elegans
- gpx-3
- Danio rerio
- gpx3
- Mus musculus
- Gpx3
- Rattus norvegicus
- Gpx3
- Saccharomyces cerevisiae
- HYR1
- Saccharomyces cerevisiae
- GPX1
In other databases
- GenAge microarray genes
- This gene is present as GPX3
GPX4
Gene details
- HGNC symbol
- GPX4
- Aliases
- MCSP; SMDS; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx
- Common name
- glutathione peroxidase 4
- Description
- The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
- Other longevity studies of this gene
- 3
- OMIM
- 138322
- Ensembl
- ENSG00000167468
- UniProt/Swiss-Prot
- GPX4_HUMAN
- Entrez Gene
- 2879
- UniGene
- 433951
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- gpx4b
- Danio rerio
- gpx4a
- Mus musculus
- Gpx4
- Rattus norvegicus
- Gpx4
- Saccharomyces cerevisiae
- HYR1
- Saccharomyces cerevisiae
- GPX1
- Schizosaccharomyces pombe
- gpx1
In other databases
GSR
Gene details
- HGNC symbol
- GSR
- Aliases
- HEL-75; HEL-S-122m
- Common name
- glutathione-disulfide reductase
- Description
- This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
- Other longevity studies of this gene
- 8
- OMIM
- 138300
- Ensembl
- ENSG00000104687
- UniProt/Swiss-Prot
- GSHR_HUMAN
- Entrez Gene
- 2936
- UniGene
- 271510
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gsr-1
- Danio rerio
- gsr
- Mus musculus
- Gsr
- Rattus norvegicus
- Gsr
- Saccharomyces cerevisiae
- GLR1
- Schizosaccharomyces pombe
- pgr1
In other databases
- GenAge human genes
- This gene is present as GSR
GSS
Gene details
- HGNC symbol
- GSS
- Aliases
- GSHS; HEL-S-64p; HEL-S-88n
- Common name
- glutathione synthetase
- Description
- Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 601002
- Ensembl
- ENSG00000100983
- UniProt/Swiss-Prot
- GSHB_HUMAN
- Entrez Gene
- 2937
- UniGene
- 82327
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gss-1
- Danio rerio
- gss
- Drosophila melanogaster
- CG32495
- Drosophila melanogaster
- GS
- Drosophila melanogaster
- GS
- Drosophila melanogaster
- CG32495
- Mus musculus
- Gss
- Rattus norvegicus
- Gss
- Saccharomyces cerevisiae
- GSH2
- Schizosaccharomyces pombe
- gsa1
In other databases
- GenAge human genes
- This gene is present as GSS
GSTM3
Gene details
- HGNC symbol
- GSTM3
- Aliases
- GST5; GSTB; GTM3; GSTM3-3
- Common name
- glutathione S-transferase mu 3
- Description
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 138390
- Ensembl
- ENSG00000134202
- UniProt/Swiss-Prot
- GSTM3_HUMAN
- Entrez Gene
- 2947
- UniGene
- 2006
- HapMap
- View on HapMap
Homologs in model organisms
GSTP1
Gene details
- HGNC symbol
- GSTP1
- Aliases
- PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
- Common name
- glutathione S-transferase pi 1
- Description
- Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 4
- OMIM
- 134660
- Ensembl
- ENSG00000084207
- UniProt/Swiss-Prot
- GSTP1_HUMAN
- Entrez Gene
- 2950
- UniGene
- 523836
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gst-23
- Caenorhabditis elegans
- gst-25
- Caenorhabditis elegans
- gst-41
- Caenorhabditis elegans
- gst-1
- Danio rerio
- gstp2
- Danio rerio
- gstp1
- Mus musculus
- Gstp1
- Mus musculus
- Gstp2
- Rattus norvegicus
- Gstp1
In other databases
LOC105372352
Gene details
- HGNC symbol
- LOC105372352
- Aliases
- CTB-32O4.2; CTB-32O4.3; CTB-32O4.4
- Common name
- uncharacterized LOC105372352
- Description
- OMIM
- Ensembl
- ENSG00000267498
- UniProt/Swiss-Prot
- Entrez Gene
- 105372352
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105376622
Gene details
- HGNC symbol
- LOC105376622
- Aliases
- Common name
- uncharacterized LOC105376622
- Description
- Other longevity studies of this gene
- 2
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105376622
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105378228
Gene details
- HGNC symbol
- LOC105378228
- Aliases
- Common name
- uncharacterized LOC105378228
- Description
- Other longevity studies of this gene
- 1
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105378228
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOX
Gene details
- HGNC symbol
- LOX
- Aliases
- AAT10
- Common name
- lysyl oxidase
- Description
- This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
- OMIM
- 153455
- Ensembl
- ENSG00000113083
- UniProt/Swiss-Prot
- B0AZT2_HUMAN
- Entrez Gene
- 4015
- UniGene
- 102267
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- LOX (1 of many)
- Danio rerio
- loxa
- Drosophila melanogaster
- lox
- Mus musculus
- Lox
- Rattus norvegicus
- Lox
In other databases
MT1A
Gene details
- HGNC symbol
- MT1A
- Aliases
- MT1; MTC; MT1S
- Common name
- metallothionein 1A
- Description
- Other longevity studies of this gene
- 2
- OMIM
- 156350
- Ensembl
- ENSG00000205362
- UniProt/Swiss-Prot
- MT1A_HUMAN
- Entrez Gene
- 4489
- UniGene
- 655199
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
MYH7B
Gene details
- HGNC symbol
- MYH7B
- Aliases
- MHC14; MYH14
- Common name
- myosin heavy chain 7B
- Description
- The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]
- OMIM
- 609928
- Ensembl
- ENSG00000078814
- UniProt/Swiss-Prot
- MYH7B_HUMAN
- Entrez Gene
- 57644
- UniGene
- 414122
- HapMap
- View on HapMap
Homologs in model organisms
NDUFV1
Gene details
- HGNC symbol
- NDUFV1
- Aliases
- UQOR1; CI-51K; CI51KD
- Common name
- NADH:ubiquinone oxidoreductase core subunit V1
- Description
- The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
- OMIM
- 161015
- Ensembl
- ENSG00000167792
- UniProt/Swiss-Prot
- E5KNH5_HUMAN
- Entrez Gene
- 4723
- UniGene
- 7744
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- nuo-1
- Danio rerio
- ndufv1
- Drosophila melanogaster
- CG11423
- Drosophila melanogaster
- CG8102
- Drosophila melanogaster
- CG9140
- Mus musculus
- Ndufv1
- Rattus norvegicus
- Ndufv1
- Schizosaccharomyces pombe
- SPBC18E5.10
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as nuo-1
NDUFV2
Gene details
- HGNC symbol
- NDUFV2
- Aliases
- CI-24k
- Common name
- NADH:ubiquinone oxidoreductase core subunit V2
- Description
- The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 6
- OMIM
- 600532
- Ensembl
- ENSG00000178127
- UniProt/Swiss-Prot
- NDUV2_HUMAN
- Entrez Gene
- 4729
- UniGene
- 464572
- HapMap
- View on HapMap
Homologs in model organisms
NOS3
Gene details
- HGNC symbol
- NOS3
- Aliases
- eNOS; ECNOS
- Common name
- nitric oxide synthase 3
- Description
- Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
- Other longevity studies of this gene
- 13
- OMIM
- 163729
- Ensembl
- ENSG00000164867
- UniProt/Swiss-Prot
- A0A0A0MTA6_HUMAN
- Entrez Gene
- 4846
- UniGene
- 647092
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Nos3
NOX1
Gene details
- HGNC symbol
- NOX1
- Aliases
- MOX1; NOH1; NOH-1; GP91-2
- Common name
- NADPH oxidase 1
- Description
- This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
- Other longevity studies of this gene
- 7
- OMIM
- 300225
- Ensembl
- ENSG00000007952
- UniProt/Swiss-Prot
- A6NGA6_HUMAN
- Entrez Gene
- 27035
- UniGene
- 592227
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- CellAge
- This gene is present as NOX1
PARK7
Gene details
- HGNC symbol
- PARK7
- Aliases
- DJ1; DJ-1; GATD2; HEL-S-67p
- Common name
- Parkinsonism associated deglycase
- Description
- The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 602533
- Ensembl
- ENSG00000116288
- UniProt/Swiss-Prot
- PARK7_HUMAN
- Entrez Gene
- 11315
- UniGene
- 419640
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- djr-1.1
- Caenorhabditis elegans
- djr-1.2
- Danio rerio
- park7
- Drosophila melanogaster
- DJ-1alpha
- Drosophila melanogaster
- dj-1beta
- Mus musculus
- Park7
- Rattus norvegicus
- Park7
- Schizosaccharomyces pombe
- SPAC22E12.03c
In other databases
PON1
Gene details
- HGNC symbol
- PON1
- Aliases
- ESA; PON; MVCD5
- Common name
- paraoxonase 1
- Description
- The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
- Other longevity studies of this gene
- 31
- OMIM
- 168820
- Ensembl
- ENSG00000005421
- UniProt/Swiss-Prot
- PON1_HUMAN
- Entrez Gene
- 5444
- UniGene
- 370995
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- poml-4
- Caenorhabditis elegans
- mec-6
- Caenorhabditis elegans
- poml-2
- Caenorhabditis elegans
- poml-3
- Danio rerio
- pon3.2
- Danio rerio
- pon3.2
- Danio rerio
- pon2
- Danio rerio
- pon1
- Mus musculus
- Pon1
- Rattus norvegicus
- Pon1
In other databases
PON2
Gene details
- HGNC symbol
- PON2
- Aliases
- Common name
- paraoxonase 2
- Description
- This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 14
- OMIM
- 602447
- Ensembl
- ENSG00000105854
- UniProt/Swiss-Prot
- A0A0J9YYG4_HUMAN
- Entrez Gene
- 5445
- UniGene
- 514420
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- poml-2
- Caenorhabditis elegans
- poml-4
- Caenorhabditis elegans
- poml-3
- Caenorhabditis elegans
- mec-6
- Danio rerio
- pon3.2
- Danio rerio
- pon3.2
- Danio rerio
- pon2
- Danio rerio
- pon1
- Mus musculus
- Pon2
- Rattus norvegicus
- Pon2
In other databases
- GenAge microarray genes
- This gene is present as PON2
PON3
Gene details
- HGNC symbol
- PON3
- Aliases
- Common name
- paraoxonase 3
- Description
- This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 602720
- Ensembl
- ENSG00000105852
- UniProt/Swiss-Prot
- PON3_HUMAN
- Entrez Gene
- 5446
- UniGene
- 440967
- HapMap
- View on HapMap
Homologs in model organisms
PPP1R9A
Gene details
- HGNC symbol
- PPP1R9A
- Aliases
- NRB1; NRBI; Neurabin-I
- Common name
- protein phosphatase 1 regulatory subunit 9A
- Description
- This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 5
- OMIM
- 602468
- Ensembl
- ENSG00000158528
- UniProt/Swiss-Prot
- A4D1I0_HUMAN
- Entrez Gene
- 55607
- UniGene
- 21816
- HapMap
- View on HapMap
Homologs in model organisms
PRDX3
Gene details
- HGNC symbol
- PRDX3
- Aliases
- AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III
- Common name
- peroxiredoxin 3
- Description
- This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
- Other longevity studies of this gene
- 5
- OMIM
- 604769
- Ensembl
- ENSG00000165672
- UniProt/Swiss-Prot
- PRDX3_HUMAN
- Entrez Gene
- 10935
- UniGene
- 523302
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- prdx-3
- Danio rerio
- prdx3
- Drosophila melanogaster
- Prx3
- Mus musculus
- Prdx3
- Rattus norvegicus
- Prdx3
- Saccharomyces cerevisiae
- TSA1
- Saccharomyces cerevisiae
- TSA2
In other databases
SOD1
Gene details
- HGNC symbol
- SOD1
- Aliases
- ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer
- Common name
- superoxide dismutase 1
- Description
- The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 147450
- Ensembl
- ENSG00000142168
- UniProt/Swiss-Prot
- SODC_HUMAN
- Entrez Gene
- 6647
- UniGene
- 443914
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sod-4
- Danio rerio
- sod1
- Drosophila melanogaster
- Sod
- Mus musculus
- Sod1
- Rattus norvegicus
- Sod1
- Saccharomyces cerevisiae
- SOD1
- Schizosaccharomyces pombe
- sod1
In other databases
SOD3
Gene details
- HGNC symbol
- SOD3
- Aliases
- EC-SOD
- Common name
- superoxide dismutase 3
- Description
- This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
- Other longevity studies of this gene
- 16
- OMIM
- 185490
- Ensembl
- ENSG00000109610
- UniProt/Swiss-Prot
- A0A140VJU8_HUMAN
- Entrez Gene
- 6649
- UniGene
- 2420
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- sod3b
- Drosophila melanogaster
- Sod3
- Mus musculus
- Sod3
- Rattus norvegicus
- Sod3
- Saccharomyces cerevisiae
- SOD1
In other databases
SRXN1
Gene details
- HGNC symbol
- SRXN1
- Aliases
- SRX; Npn3; SRX1; C20orf139
- Common name
- sulfiredoxin 1
- Description
- Other longevity studies of this gene
- 4
- OMIM
- Ensembl
- ENSG00000271303
- UniProt/Swiss-Prot
- SRXN1_HUMAN
- Entrez Gene
- 140809
- UniGene
- 516830
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- srxn1
- Drosophila melanogaster
- CG6762
- Mus musculus
- Srxn1
- Rattus norvegicus
- Srxn1
- Saccharomyces cerevisiae
- SRX1
- Schizosaccharomyces pombe
- srx1
In other databases
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SRX1
TXN2
Gene details
- HGNC symbol
- TXN2
- Aliases
- TXN; MTRX; TRX2; MT-TRX; COXPD29
- Common name
- thioredoxin 2
- Description
- This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 609063
- Ensembl
- ENSG00000100348
- UniProt/Swiss-Prot
- B4DX69_HUMAN
- Entrez Gene
- 25828
- UniGene
- 211929
- HapMap
- View on HapMap
Homologs in model organisms
UCP1
Gene details
- HGNC symbol
- UCP1
- Aliases
- UCP; SLC25A7
- Common name
- uncoupling protein 1
- Description
- Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 11
- OMIM
- 113730
- Ensembl
- ENSG00000109424
- UniProt/Swiss-Prot
- Q4KMT7_HUMAN
- Entrez Gene
- 7350
- UniGene
- 249211
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- ucp1
- Mus musculus
- Ucp1
- Rattus norvegicus
- Ucp1
- Rattus norvegicus
- LOC100909612
- Saccharomyces cerevisiae
- DIC1
In other databases
- GenAge human genes
- This gene is present as UCP1
UCP2
Gene details
- HGNC symbol
- UCP2
- Aliases
- UCPH; BMIQ4; SLC25A8
- Common name
- uncoupling protein 2
- Description
- Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 601693
- Ensembl
- ENSG00000175567
- UniProt/Swiss-Prot
- A0A024R5N5_HUMAN
- Entrez Gene
- 7351
- UniGene
- 80658
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
UQCRFS1
Gene details
- HGNC symbol
- UQCRFS1
- Aliases
- RIP1; RIS1; RISP; UQCR5
- Common name
- ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
- Description
- Other longevity studies of this gene
- 2
- OMIM
- 191327
- Ensembl
- ENSG00000169021
- UniProt/Swiss-Prot
- UCRI_HUMAN
- Entrez Gene
- 7386
- UniGene
- 743307
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- isp-1
- Danio rerio
- uqcrfs1
- Drosophila melanogaster
- RFeSP
- Mus musculus
- Uqcrfs1
- Rattus norvegicus
- Uqcrfs1
- Saccharomyces cerevisiae
- RIP1
In other databases
XDH
Gene details
- HGNC symbol
- XDH
- Aliases
- XO; XOR; XAN1
- Common name
- xanthine dehydrogenase
- Description
- Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
- Other longevity studies of this gene
- 23
- OMIM
- 607633
- Ensembl
- ENSG00000158125
- UniProt/Swiss-Prot
- XDH_HUMAN
- Entrez Gene
- 7498
- UniGene
- 250
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- F55B11.1
- Caenorhabditis elegans
- gad-3
- Caenorhabditis elegans
- F15E6.6
- Danio rerio
- xdh
- Drosophila melanogaster
- AOX4
- Drosophila melanogaster
- ry
- Drosophila melanogaster
- AOX1
- Drosophila melanogaster
- AOX2
- Drosophila melanogaster
- AOX3
- Mus musculus
- Xdh
- Rattus norvegicus
- Xdh