LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- I105V SNP was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years
- Conclusions
- There were slightly fewer observed heterozygous 105IV genotypes and more homozygous 105VV genotypes
- Identifier
- I105V
- Cytogenetic Location
- 11q13.2
- UCSC Genome Browser
- View 11q13.2 on the UCSC genome browser
Gene details
- HGNC symbol
- GSTP1
- Aliases
- PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
- Common name
- glutathione S-transferase pi 1
- Description
- Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 4
- OMIM
- 134660
- Ensembl
- ENSG00000084207
- UniProt/Swiss-Prot
- GSTP1_HUMAN
- Entrez Gene
- 2950
- UniGene
- 523836
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gst-23
- Caenorhabditis elegans
- gst-25
- Caenorhabditis elegans
- gst-41
- Caenorhabditis elegans
- gst-1
- Danio rerio
- gstp2
- Danio rerio
- gstp1
- Mus musculus
- Gstp1
- Mus musculus
- Gstp2
- Rattus norvegicus
- Gstp1