LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 1651 participants in the Danish 1905 cohort study (aged 92-93 years) were genotyped for two SNPs (rs2866164 and Q95H). Furthermore, a group of 575 middle-aged Danish twins (mean age 53.7 years) were tested as a younger control group.
- Conclusions
- The risk haplotype had no significant survival disadvantage after 6.5 years of follow-up. The distributions of the suggested risk alleles and the resulting haplotypes were not statistically different between the two age cohorts.
Variants (2)
1.
2.
- Identifier
- Q95H
- In Other Studies (IDs)
- 446
- Cytogenetic Location
- 4q23
- UCSC Genome Browser
- View 4q23 on the UCSC genome browser
Gene details
- HGNC symbol
- MTTP
- Aliases
- ABL; MTP
- Common name
- microsomal triglyceride transfer protein
- Description
- MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 20
- OMIM
- 157147
- Ensembl
- ENSG00000138823
- UniProt/Swiss-Prot
- B7Z7X3_HUMAN
- Entrez Gene
- 4547
- UniGene
- 195799
- HapMap
- View on HapMap