LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
German
Study Design
rs1800591, rs2866164, and Q/H 95 SNPs were examined in 1,039 unrelated individuals between 95 and 109 years of age (mean age, 98.2 years); 373 (36%) of the long-lived participants were centenarians or supercentenarians (mean age, 101.4 years). The sex ratio in the entire sample was 74% females vs. 26% males. A total of 540 control individuals aged between 60 and 75 years (mean age, 67.2 years) were used.
Conclusions
No evidence for association was detected between any of the tested SNPs at the allele or at the genotype level
Identifier
rs2866164
In Other Studies (IDs)
1945 2068 2082 3461
Cytogenetic Location
4q23
UCSC Genome Browser
View 4q23 on the UCSC genome browser

Gene details

HGNC symbol
MTTP
Aliases
ABL; MTP 
Common name
microsomal triglyceride transfer protein 
Description
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
20
OMIM
157147
Ensembl
ENSG00000138823
UniProt/Swiss-Prot
B7Z7X3_HUMAN
Entrez Gene
4547
UniGene
195799
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
mtp
Drosophila melanogaster
Mtp
Mus musculus
Mttp
Rattus norvegicus
Mttp

References

Nebel et al. (2005)

Other variants which are also part of this study