GenAge entry for HELLS (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 101)
- HGNC symbol
- HELLS
- Aliases
- PASG; SMARCA6; LSH; Nbla10143
- Common name
- helicase, lymphoid-specific
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
HELLS is a transcriptional regulator acting on chromatin and maybe affecting cellular proliferation. It has been linked to leukaemia [1047]. About 60% of HELLS-null mice die shortly after birth. Survivors do not commonly live more than a month but exhibit growth retardation and signs of premature ageing [1045]. Whether HELLS impacts on human ageing is unknown.
Cytogenetic information
- Cytogenetic band
- 10q24.2
- Location
- 94,545,767 bp to 94,602,099 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006346; methylation-dependent chromatin silencing
GO:0006351; transcription, DNA-templated
GO:0007067; mitotic nuclear division
GO:0007275; multicellular organism development
GO:0010216; maintenance of DNA methylation
GO:0031508; pericentric heterochromatin assembly
GO:0046651; lymphocyte proliferation
GO:0051301; cell division
Cellular component: GO:0000775; chromosome, centromeric region
GO:0005634; nucleus
GO:0005721; pericentric heterochromatin
Function: GO:0004386; helicase activity
GO:0005515; protein binding
GO:0005524; ATP binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- MYC, EGFR, VCP, APP, HDAC1, HDAC2
- STRING interaction network
Retrieve sequences for HELLS
Homologs in model organisms
- Danio rerio
- hells
- Mus musculus
- Hells
- Rattus norvegicus
- Hells
- Rattus norvegicus
- LOC100911660
- Rattus norvegicus
- Hells
- Rattus norvegicus
- LOC100911660
- Saccharomyces cerevisiae
- IRC5
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Hells
- CellAge
- This gene is present as HELLS
- CellAge gene expression
- This gene is present as HELLS
Selected references
External links
- EPD
- ORF Accession
- NM_018063
- CDS Accession
- NP_060533
- OMIM
- 603946
- HPRD
- 07232
- Ensembl
- HELLS
- UniProt/Swiss-Prot
- HELLS_HUMAN
- GeneCards
- HELLS
- Entrez Gene
- 3070
- GenAtlas
- HELLS
- Internet
- Search Google