LongevityMap Gene
Gene details
- HGNC symbol
- SSTR3
- Aliases
- SS3R; SS3-R; SS-3-R; SSR-28
- Common name
- somatostatin receptor 3
- Description
- This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- Cytogenetic Location
- 22q13.1
- UCSC Genome Browser
- View 22q13.1 on the UCSC genome browser
- OMIM
- 182453
- Ensembl
- ENSG00000278195
- UniProt/Swiss-Prot
- SSR3_HUMAN
- Entrez Gene
- 6753
- UniGene
- 225995
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as SSTR3
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
- Indentifier
- rs13053175
- Reference