LongevityMap Gene
Gene details
- HGNC symbol
- CDKN2B
- Aliases
- P15; MTS2; TP15; CDK4I; INK4B; p15INK4b
- Common name
- cyclin dependent kinase inhibitor 2B
- Description
- This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 9p21.3
- UCSC Genome Browser
- View 9p21.3 on the UCSC genome browser
- OMIM
- 600431
- Ensembl
- ENSG00000147883
- UniProt/Swiss-Prot
- CDN2B_HUMAN
- Entrez Gene
- 1030
- UniGene
- 72901
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as CDKN2B
- CellAge
- This gene is present as CDKN2B
- CellAge gene expression
- This gene is present as CDKN2B
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs1063192
- Reference