LongevityMap Gene
Gene details
- HGNC symbol
- AGTR1
- Aliases
- AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
- Common name
- angiotensin II receptor type 1
- Description
- Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
- Cytogenetic Location
- 3q24
- UCSC Genome Browser
- View 3q24 on the UCSC genome browser
- OMIM
- 106165
- Ensembl
- ENSG00000144891
- UniProt/Swiss-Prot
- A0A0A0MSE3_HUMAN
- Entrez Gene
- 185
- UniGene
- 477887
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- agtr1a
- Danio rerio
- agtr1b
- Mus musculus
- Agtr1b
- Mus musculus
- Agtr1a
- Rattus norvegicus
- Agtr1a
- Rattus norvegicus
- Agtr1b
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Agtr1a
- GenAge human genes
- This gene is present as AGTR1
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Significant
- Population
- Italian (Northern) and Japanese
- Study Design
- AGTR1 was sequenced in 173 Italian centenarians (99-106 y, mean 100.9 ± 1.7 y, 83% female) and 376 younger controls (49-78 y, mean 65.9 ± 9.1 y, 43 % females). The results were then verified in 589 Japanese cases (99-115 y, mean 104.5 ± 3 y, 84% femal) and 422 controls (69-72 y, mean 70.1 ± 0.9 y, 52 % female).
- Conclusions
- rs422858, rs275653 were significantly associated with extreme longevity (P = 0.004). Combining the Italian and Japanese cohorts, rs275653 was associated to extreme longevity either at recessive model (P = 0.007, odds ratio (OR) 3.57) or at genotype level (P = 0.015).
- Indentifier
- rs422858
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian (Northern) and Japanese
- Study Design
- AGTR1 was sequenced in 173 Italian centenarians (99-106 y, mean 100.9 ± 1.7 y, 83% female) and 376 younger controls (49-78 y, mean 65.9 ± 9.1 y, 43 % females). The results were then verified in 589 Japanese cases (99-115 y, mean 104.5 ± 3 y, 84% femal) and 422 controls (69-72 y, mean 70.1 ± 0.9 y, 52 % female).
- Conclusions
- rs422858, rs275653 were significantly associated with extreme longevity (P = 0.004). Other SNPs were not associated with longevity.
- Indentifier
- rs2307085
- Reference