Caenorhabditis elegansGenAge entry for set-2 (Caenorhabditis elegans)

Gene information (ID: 977)

Symbol
set-2
Name
SET (trithorax/polycomb) domain containing
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
20% mean lifespan extension
% change in avg or median lifespan
Average lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Set-2 deficiency in the parental generation extend the lifespan of descendants up until the third generation.
    % change in avg or median lifespan
    Lifespan is up to 30% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as SET1
      CellAge
      • A homolog of this gene for Homo sapiens is present as SETD1A

      Homologs in other organisms

      Danio rerio
      setd1ba
      Danio rerio
      setd1a
      Danio rerio
      setd1bb
      Drosophila melanogaster
      Set1
      Homo sapiens
      SETD1B
      Homo sapiens
      SETD1A
      Mus musculus
      Setd1a
      Mus musculus
      RP23-325D10.3
      Mus musculus
      Setd1b
      Rattus norvegicus
      Setd1a
      Rattus norvegicus
      Setd1b
      Saccharomyces cerevisiae
      SET1

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (175662)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar