- Symbol
- Hnrnpd
- Aliases
- Auf1; Hnrpd
- Name
- heterogeneous nuclear ribonucleoprotein D
- Organism
- Mus musculus (AnAge)
- Observations
- AUF1-deficient mice undergo striking telomere erosion, markedly increased DNA damage responses at telomere ends, pronounced cellular senescence, and rapid premature aging that increases with successive generations, which can be rescued in AUF1 knockout mice and their cultured cells by resupplying AUF1 expression. Auf1 -/- mice in all genetic backgrounds displayed classic hallmarks of accelerated aging, including kyphosis (hunchback), reduced subcutaneous body fat, and atrophy of the reproductive organs in most animals by 12 months of age
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge
- A homolog of this gene for Homo sapiens is present as HNRNPD
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as HNRNPD
- Danio rerio
- hnrnpd
- Drosophila melanogaster
- sqd
- Homo sapiens
- HNRNPD
- Rattus norvegicus
- Hnrnpd
- Saccharomyces cerevisiae
- HRP1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (11991)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Hnrnpd (Mus musculus)