Cell Senescence Entries for HNRNPD

Cell Types
Aortic endothelial, Breast cancer
Cell Lines
MDA-MB-231, Primary cell
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Al-Khalaf et al. (2017) p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1. Mol Carcinog 56(3)985-999 (PubMed)

HNRNPD Gene Information

HGNC symbol
HNRNPD 
Aliases
AUF1; HNRPD 
Common name
heterogeneous nuclear ribonucleoprotein D 
Entrez Id
3184
Description
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008].

HNRNPD Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:10468; regulation of gene expression
GO:1889; liver development
GO:7420; brain development
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:21549; cerebellum development
GO:32204; regulation of telomere maintenance
GO:32355; response to estradiol
And 25 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:110165; cellular anatomical entity
GO:5654; nucleoplasm
GO:1990904; ribonucleoprotein complex
GO:5829; cytosol
GO:45202; synapse
GO:106002; mCRD-mediated mRNA stability complex
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:3677; DNA binding
GO:5515; protein binding
GO:3680; minor groove of adenine-thymine-rich DNA binding
GO:3682; chromatin binding
GO:3729; mRNA binding
GO:35925; mRNA 3'-UTR AU-rich region binding
GO:42826; histone deacetylase binding
GO:42162; telomeric DNA binding
Show all GO terms

Homologs of HNRNPD in Model Organisms

Danio rerio
hnrnpd
Drosophila melanogaster
sqd
Mus musculus
Hnrnpd
Rattus norvegicus
Hnrnpd
Saccharomyces cerevisiae
HRP1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Hnrnpd
CellAge gene expression
  • This gene is present as HNRNPD

External links

OMIM
601324
Ensembl
ENSG00000138668
Entrez Gene
3184
UniGene
480073
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HNRNPD
GeneCards
HNRNPD