- Symbol
- Bub1b
- Aliases
- BUBR1; AU045529
- Name
- budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Kinase involved in the spindle checkpoint function
- Observations
- Overexpression of BubR1 preserves genomic integrity, reduces tumorigenesis and extends average and maximum lifespan.
- % change in max lifespan
- Maximum lifespan is 18% higher.
- % change in avg or median lifespan
- Average lifespan is 14% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Knockout mutant mice exhibit symptoms of accelerated ageing such as short lifespan, lordokyphosis, and fat loss.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as BUB1B
- CellAge
- A homolog of this gene for Homo sapiens is present as BUB1B
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as BUB1B
- Caenorhabditis elegans
- bub-1
- Danio rerio
- bub1bb
- Drosophila melanogaster
- BubR1
- Drosophila melanogaster
- Bub1
- Homo sapiens
- BUB1B
- Rattus norvegicus
- Bub1b
- Saccharomyces cerevisiae
- MAD3
- Saccharomyces cerevisiae
- BUB1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (12236)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Bub1b (Mus musculus)