Cell Senescence Entries for BUB1B

Cell Types
Colorectal cancer, Melanoma
Cell Lines
A375P, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

BUB1B Gene Information

HGNC symbol
BUB1B 
Aliases
Bub1A; BUBR1; MAD3L; SSK1 
Common name
BUB1 mitotic checkpoint serine/threonine kinase B 
Entrez Id
701
Description
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].

BUB1B Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:6468; protein phosphorylation
GO:51301; cell division
GO:51754; meiotic sister chromatid cohesion, centromeric
GO:7094; mitotic spindle assembly checkpoint signaling
GO:51444; negative regulation of ubiquitin-protein transferase activity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:5815; microtubule organizing center
GO:5819; spindle
GO:776; kinetochore
GO:48471; perinuclear region of cytoplasm
GO:33597; mitotic checkpoint complex
And 4 more GO terms
Function: GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4672; protein kinase activity
Show all GO terms

Homologs of BUB1B in Model Organisms

Caenorhabditis elegans
bub-1
Danio rerio
bub1bb
Drosophila melanogaster
BubR1
Drosophila melanogaster
Bub1
Mus musculus
Bub1b
Rattus norvegicus
Bub1b
Saccharomyces cerevisiae
MAD3
Saccharomyces cerevisiae
BUB1
Schizosaccharomyces pombe
bub1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Bub1b
GenAge human genes
  • This gene is present as BUB1B
CellAge gene expression
  • This gene is present as BUB1B

External links

OMIM
602860
Ensembl
ENSG00000156970
Entrez Gene
701
UniGene
513645
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BUB1B
GeneCards
BUB1B