Cell Senescence Entries for BUB1B
- Cell Types
- Colorectal cancer, Melanoma
- Cell Lines
- A375P, HCT116
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)
BUB1B Gene Information
- HGNC symbol
- BUB1B
- Aliases
- Bub1A; BUBR1; MAD3L; SSK1
- Common name
- BUB1 mitotic checkpoint serine/threonine kinase B
- Entrez Id
- 701
- Description
- This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].
BUB1B Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:6468; protein phosphorylation
GO:51301; cell division
GO:51754; meiotic sister chromatid cohesion, centromeric
GO:7094; mitotic spindle assembly checkpoint signaling
GO:51444; negative regulation of ubiquitin-protein transferase activity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:5815; microtubule organizing center
GO:5819; spindle
GO:776; kinetochore
GO:48471; perinuclear region of cytoplasm
GO:33597; mitotic checkpoint complex
And 4 more GO terms
Show all GO termsFunction: GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4672; protein kinase activity
Homologs of BUB1B in Model Organisms
- Caenorhabditis elegans
- bub-1
- Danio rerio
- bub1bb
- Drosophila melanogaster
- BubR1
- Drosophila melanogaster
- Bub1
- Mus musculus
- Bub1b
- Rattus norvegicus
- Bub1b
- Saccharomyces cerevisiae
- MAD3
- Saccharomyces cerevisiae
- BUB1
- Schizosaccharomyces pombe
- bub1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Bub1b
- GenAge human genes
- This gene is present as BUB1B
- CellAge gene expression
- This gene is present as BUB1B
External links
- OMIM
- 602860
- Ensembl
- ENSG00000156970
- Entrez Gene
- 701
- UniGene
- 513645
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- BUB1B
- GeneCards
- BUB1B