- Symbol
- LAT1
- Aliases
- ODP2; PDA2
- Name
- Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- Dihydrolipoamide acetyltransferase
- Observations
- Deletion abolished the lifespan extension conferred by calorie restriction. Overexpression extended mean lifespan by 20%, did not further extend lifespan under CR, and was not dependent on the Sir2 family. Overexpression also extended cell survival during prolonged culture at stationary phase.
- % change in avg or median lifespan
- Average lifespan is 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as dlat-1
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as DLAT
- A homolog of this gene for Homo sapiens is present as PDHX
- GenDR gene manipulations
- This gene is present as LAT1
- Caenorhabditis elegans
- dlat-1
- Caenorhabditis elegans
- C30H6.7
- Danio rerio
- dlat
- Danio rerio
- pdhx
- Drosophila melanogaster
- CG5261
- Homo sapiens
- PDHX
- Homo sapiens
- DLAT
- Mus musculus
- Pdhx
- Mus musculus
- Dlat
- Rattus norvegicus
- Dlat
- Rattus norvegicus
- Pdhx
- Schizosaccharomyces pombe
- lat1
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (855653)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for LAT1 (Saccharomyces cerevisiae)