- Symbol
- SNF1A
- Aliases
- ampk; AMPK; ampkalpha; AMPKalpha; CG3051; dAMPKa; dAMPKa
- Name
- SNF1A/AMP-activated protein kinase
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Transgenic expression of AMPK in adult fat body or adult muscle, key metabolic tissues, extended life span, while AMPK RNAi reduced life span. Supplementing adenine, a substrate for AMP biosynthesis, to the diet of long-lived AMP biosynthesis mutants reversed life span extension.
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Transgenic expression of AMPK in adult fat body or adult muscle, key metabolic tissues, extended life span, while AMPK RNAi reduced life span. Supplementing adenine, a substrate for AMP biosynthesis, to the diet of long-lived AMP biosynthesis mutants reversed life span extension.
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Adult-onset, neuron-specific upregulation of the catalytic alpha AMPK subunit results in increased median lifespan in female flies and has variable effects on male lifespan. This longevity effect is dependent on Atg1 gene activity.
- % change in avg or median lifespan
- Median lifespan is up to 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as aak-2
- A homolog of this gene for Saccharomyces cerevisiae is present as SNF1
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as aak-2
- LongevityMap
- A homolog of this gene for Homo sapiens is present as PRKAA1
- CellAge
- A homolog of this gene for Homo sapiens is present as PRKAA2
- Caenorhabditis elegans
- aak-1
- Caenorhabditis elegans
- aak-2
- Danio rerio
- prkaa1
- Danio rerio
- prkaa2
- Homo sapiens
- PRKAA1
- Homo sapiens
- PRKAA2
- Mus musculus
- Prkaa1
- Mus musculus
- Prkaa2
- Rattus norvegicus
- Prkaa2
- Rattus norvegicus
- Prkaa1
- Saccharomyces cerevisiae
- SNF1
- Schizosaccharomyces pombe
- ssp2
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (43904)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for SNF1A (Drosophila melanogaster)