- Symbol
- Pten
- Aliases
- TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B4
- Name
- Phosphatase and tensin homolog
- Organism
- Mus musculus (AnAge)
- Observations
- Median survival for Pten+/- male and female mice was 417 and 289 days, respectively (compared with >650 days for wild type C57BL6 mice), with deaths due to early cancer development, mainly lymphomas. Survival of Pten+/- mice was reduced to <40% normal life span due to early tumor development. Inhibition of mTor kinase with rapamycin, a downstream effector of Akt, inhibits lymphomagenesis and extends the survival of Pten+/- mice.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Pten(tg) mice carrying additional genomic copies of Pten are protected from cancer and present a significant extension of life span that is independent of their lower cancer incidence. In addition, mutant mice displayed enchanced protection from insulin resistance and steatosis, an increased energy expenditure and a hyperactive brown adipose tissue.
- % change in max lifespan
- Maximum lifespan was up to 16% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as daf-18
- A homolog of this gene for Drosophila melanogaster is present as Pten
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PTEN
- CellAge
- A homolog of this gene for Homo sapiens is present as PTEN
- Caenorhabditis elegans
- daf-18
- Danio rerio
- ptenb
- Drosophila melanogaster
- Pten
- Homo sapiens
- PTEN
- Rattus norvegicus
- Pten
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (19211)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Pten (Mus musculus)