Cell Senescence Entries for PTEN

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Jung et al. (2019) mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53. Oncogene 38(10)1639-1650 (PubMed)

PTEN Gene Information

HGNC symbol
PTEN 
Aliases
BZS; MHAM; MMAC1; PTEN1; TEP1 
Common name
phosphatase and tensin homolog 
Entrez Id
5728
Description
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015].

PTEN Ontologies

Gene Ontology
Process: GO:16311; dephosphorylation
GO:6629; lipid metabolic process
GO:35335; peptidyl-tyrosine dephosphorylation
GO:7399; nervous system development
GO:6470; protein dephosphorylation
GO:46855; inositol phosphate dephosphorylation
GO:8285; negative regulation of cell population proliferation
GO:46856; phosphatidylinositol dephosphorylation
GO:6915; apoptotic process
GO:7507; heart development
GO:16477; cell migration
And 83 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:45202; synapse
GO:16605; PML body
GO:5886; plasma membrane
GO:5576; extracellular region
GO:16324; apical plasma membrane
GO:42995; cell projection
GO:35749; myelin sheath adaxonal region
And 4 more GO terms
Function: GO:16791; phosphatase activity
GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:4438; phosphatidylinositol-3-phosphatase activity
GO:4725; protein tyrosine phosphatase activity
GO:16314; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:51717; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:51800; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
And 9 more GO terms
Show all GO terms

Homologs of PTEN in Model Organisms

Caenorhabditis elegans
daf-18
Danio rerio
ptenb
Drosophila melanogaster
Pten
Mus musculus
Pten
Rattus norvegicus
Pten

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-18
  • A homolog of this gene for Drosophila melanogaster is present as Pten
  • A homolog of this gene for Mus musculus is present as Pten
GenAge human genes
  • This gene is present as PTEN

External links

OMIM
601728
Ensembl
ENSG00000171862
Entrez Gene
5728
UniGene
729457
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PTEN
GeneCards
PTEN