Cell Senescence Entries for MITF

Cell Types
Melanoma
Cell Lines
ST-Mel
Cancer Cell?
Yes
Method
Mutation
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Primary Reference
Bonet et al. (2017) Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression. J Natl Cancer Inst 109(8)117-26 (PubMed)

MITF Gene Information

HGNC symbol
MITF 
Aliases
bHLHe32; MI; WS2; WS2A 
Common name
melanocyte inducing transcription factor 
Entrez Id
4286
Description
The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017].

MITF Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:65003; protein-containing complex assembly
GO:30336; negative regulation of cell migration
GO:10468; regulation of gene expression
GO:16055; Wnt signaling pathway
GO:30154; cell differentiation
And 13 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3700; DNA-binding transcription factor activity
GO:46983; protein dimerization activity
GO:3677; DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:70888; E-box binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:3682; chromatin binding
Show all GO terms

Homologs of MITF in Model Organisms

Caenorhabditis elegans
hlh-30
Danio rerio
mitfb
Danio rerio
mitfa
Drosophila melanogaster
Mitf
Mus musculus
Mitf
Rattus norvegicus
Mitf

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as hlh-30

External links

OMIM
156845
Ensembl
ENSG00000187098
Entrez Gene
4286
UniGene
618266
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MITF
GeneCards
MITF