LongevityMap Gene
Gene details
- HGNC symbol
- COQ7
- Aliases
- CAT5; CLK1; CLK-1; COQ10D8
- Common name
- coenzyme Q7, hydroxylase
- Description
- The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
- Cytogenetic Location
- 16p12.3
- UCSC Genome Browser
- View 16p12.3 on the UCSC genome browser
- OMIM
- 601683
- Ensembl
- ENSG00000167186
- UniProt/Swiss-Prot
- COQ7_HUMAN
- Entrez Gene
- 10229
- UniGene
- 157113
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- clk-1
- Danio rerio
- coq7
- Drosophila melanogaster
- COQ7
- Mus musculus
- Coq7
- Rattus norvegicus
- Coq7
- Saccharomyces cerevisiae
- CAT5
- Schizosaccharomyces pombe
- coq7
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as COQ7
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as clk-1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American of Japanese origin
- Study Design
- Nested-case control study of 5 candidate longevity genes in 8006 Japanese American men from the Honolulu Heart Program and 3741 men part of the Honolulu Asia Aging Study
- Conclusions
- Genetic variants in ADIPOQ, FOXO1A, SIRT1 and COQ7 were not associated with longevity
- Indentifier
- rs8051232
- Reference