DrugAge entry for Zearalenone

Name: Zearalenone
Synonyms: (-)-Zearalenone • (10S)-Zearalenone • (3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione • (S)-(-)-Zearalenone • (S)-Zearalenone • (S-(E))-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione • 17924-92-4 • 5W827M159J • 6-(10-Hydroxy-6-oxo-trans-1-undecenyl)-beta-resorcylic acid lactone • CHEBI:10106 • CHEMBL454173 • Compound F-2 • DSSTox_CID_1460 • DSSTox_GSID_21460 • DSSTox_RID_76167 • F-2 toxin • MFCD00133085 • MLS000097901 • Mycotoxin F2 • SMR000058177 • Toxin F2 • trans-Zearalenone • UNII-5W827M159J • ZEARALENONE • Zenone
CAS Number: 17924-92-4
IUPAC Name: (4S,12E)-16,18-dihydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
PubChem CID: 5281576

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Zearalenone

Average/Median Lifespan
Max Lifespan
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References

Huang, CW et al. (2021) Chronic exposure of zearalenone inhibits antioxidant defense and results in aging-related defects associated with DAF-16/FOXO in Caenorhabditis elegans. Environ Pollut 285()117233 PubMed

DGIdb Human Drug-Gene Interactions for Zearalenone

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Zearalenone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id