DrugAge entry for Wortmannin

Name: Wortmannin
Synonyms: (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione • (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate • (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate • (1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate • 19545-26-7 • Antibiotic SL-2052 • BIW4201 • BRN 0067676 • C23H24O8 • CHEBI:52289 • CHEMBL428496 • KY 12420 • MFCD00133927 • MLS002703028 • nchembio866-comp1 • NSC 627609 • NSC221019 • NSC627609 • Pi 3-Kinase Inhibitor • SL-2052 • UNII-XVA4O219QW • Wartmannin • wortmannin • Wortmannin, Wm
CAS Number: 19545-26-7
IUPAC Name
PubChem CID: 312145
SEP-L1000 side effects: Abdominal pain, Arthralgia, Asthenia, Body temperature increased, Cardiac failure congestive, Cataract, Confusional state, Constipation, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Erythema, Haemorrhage, Headache, Hyperhidrosis, Hypersensitivity, Hypertension, Infection, Influenza, Insomnia, Jaundice, Leukopenia, Myalgia, Nausea, Oedema, Pain, Paraesthesia, Pneumonia, Pruritus, Rash, Thrombocytopenia, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Wortmannin

Average/Median Lifespan
Max Lifespan
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References

Danilov, A et al. (2013) Selective anticancer agents suppress aging in Drosophila. Oncotarget 4(9)1507-1526 PubMed
Bharill P, et al. (2013) Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants Frontiers in Genetics () PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Wortmannin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Wortmannin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id