DrugAge entry for Vortioxetine

Name: Vortioxetine
Synonyms: 1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl}piperazine • 1-(2-((2,4-Dimethylphenyl)thio)phenyl)piperazine • 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine • 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine • 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine • 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine • 1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine • 3O2K1S3WQV • 508233-74-7 • 508233-74-7 (free base) • Brintellix • Brintellix (TN) • CHEBI:76016 • CHEMBL2204360 • Lu AA21004 • LuAA21004 • Piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)- • Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]- • Trintellix • UNII-3O2K1S3WQV • vortioxetina • VORTIOXETINE • Vortioxetine free base • Vortioxetine [USAN:INN] • vortioxetinum
CAS Number: 508233-74-7
IUPAC Name: 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine
PubChem CID: 9966051

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Vortioxetine

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Vortioxetine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Vortioxetine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id