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DrugAge entry for Vincristine sulfate

Name
Vincristine sulfate 
Synonyms
(3aR,3a1R,4R,5S,5aR,10bR)-methyl 4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate. • 2068-78-2 • 2068-78-2 (sulfate) • 22-oxovincaleukoblastine sulfate • AK206276 • CCRIS 2583 • CHEBI:79401 • Kyocristine • Leurocristine • Leurocristine sulfate • Leurocristine sulfate (1:1) (salt) • Leurocristine, sulfate (1:1) (salt) • Lilly 37231 • Marqibo (TN) • MLS002702994 • NSC 67574 • NSC-67574 • NSC67574 • Oncovin • Oncovin (Lilly) • Oncovin (TN) • Onkovin • VCR sulfate • Vincaleukoblastine, 22-oxo-, sulfate (1:1) • Vincasar (TN) • Vincasar PFS • Vincrex • Vincristine sulfate • Vincristine Sulfate PFS • Vincristine sulphate • Vincristinsulfat [German] • Vincrisul 
CAS Number
2068-78-2 
IUPAC Name
 
PubChem CID
249332 
SEP-L1000 side effects
Abdominal pain, Agitation, Alopecia, Amenorrhoea, Anaemia, Anaphylactic shock, Anorectal disorder, Arrhythmia, Arterial disorder, Arthralgia, Ataxia, Atrophy, Autonomic neuropathy, Azoospermia, Azotaemia, Back pain, Blindness, Blindness cortical, Body temperature increased, Bone marrow failure, Bone pain, Bronchospasm, Cachexia, Coma, Constipation, Convulsion, Coronary artery disease, Deafness, Decreased appetite, Dehydration, Depression, Diarrhoea, Diplopia, Dizziness, Dysphonia, Dyspnoea, Dysuria, Encephalopathy, Extravasation, Eyelid ptosis, Febrile neutropenia, Gait disturbance, Hallucination, Headache, Hearing impaired, Hyperhidrosis, Hypersensitivity, Hypertension, Hyperuricaemia, Hyponatraemia, Hypotension, Ileus, Ileus paralytic, Inappropriate antidiuretic hormone secretion, Incontinence, Infarction, Insomnia, Leukopenia, Malaise, Menorrhagia, Mouth ulceration, Muscle atrophy, Muscle spasms, Muscle twitching, Myalgia, Myocardial infarction, Myoclonus, Nausea, Necrosis, Neuropathy peripheral, Neutropen 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Vincristine sulfate


References

Ye, X et al. (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13(2)206-215 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Vincristine sulfate

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Vincristine sulfate

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id