DrugAge entry for Ursolic acid

Name: Ursolic acid
Synonyms: (+)-Ursolic acid • (3beta)-3-Hydroxyurs-12-en-28-oic acid • .beta.-Ursolic acid • 3beta-Hydroxy-12-ursen-28-ic acid • 3beta-Hydroxyurs-12-en-28-oic acid • 77-52-1 • CHEBI:9908 • CHEMBL169 • HNMR • Malol • NSC 167406 • NSC-167406 • NSC-4060 • NSC4060 • P3M2575F3F • Prunol • UNII-P3M2575F3F • Ursolic acid • ursolic-acid • Urson
CAS Number: 77-52-1
IUPAC Name: (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
PubChem CID: 64945

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Ursolic acid

Average/Median Lifespan
Max Lifespan
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References

Negi H, et al. (2016) 3β-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1. Send to Biochem Biophys Res Commun () PubMed
Negi H, et al. (2017) 3β-Hydroxy-urs-12-en-28-oic Acid Modulates Dietary Restriction Mediated Longevity and Ameliorates Toxic Protein Aggregation in C. elegans The journals of gerontology () PubMed
Staats S, et al. (2018) Dietary ursolic acid improves health span and life span in male Drosophila melanogaster Biofactors () PubMed
Harrison, DE et al. (2019) Acarbose improves health and lifespan in aging HET3 mice. Aging Cell 18(2)e12898 PubMed

DGIdb Human Drug-Gene Interactions for Ursolic acid

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Ursolic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id