DrugAge entry for Trimethadione

Name: Trimethadione
Synonyms: 127-48-0 • Absentol • Absetil • Convenixa • Convexina • Edion • Epidione • Epixal • Petidion • Petidon • Petilep • Petimalin • Ptimal • Tioxanona • Tridilona • Tridion • Tridione • Trimedal • Trimetadione • Trimethadion • trimethadione • Trimethin • Trimetin • Trioxanona • Troxidone
CAS Number: 127-48-0
IUPAC Name: 3,5,5-trimethyl-1,3-oxazolidine-2,4-dione
PubChem CID: 5576
SEP-L1000 side effects: Abdominal pain, Anaemia, Arthralgia, Asthenia, Body temperature increased, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Fatigue, Headache, Hypersensitivity, Hypotension, Nausea, Oedema, Pain, Pruritus, Rash, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Trimethadione

Average/Median Lifespan
Max Lifespan
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References

Evason, K et al. (2005) Anticonvulsant medications extend worm life-span. Science 307(5707)258-262 PubMed
Shibamura, A et al. (2009) A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. 130(9)652-655 PubMed

DGIdb Human Drug-Gene Interactions for Trimethadione

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Trimethadione

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id