DrugAge entry for Tomatidine

Name: Tomatidine
Synonyms: (22S,25S)-5alpha-spirosolan-3beta-ol • (3beta,5alpha,22beta,25S)-Spirosolan-3-ol • (3beta,5alpha,25S)-spirosolan-3-ol • 2B73S48786 • 5alpha-Tomatidan-3beta-ol • 5alpha-Tomatidan-3beta-ol (8CI) • 77-59-8 • AC1L23J5 • BPBio1_000426 • BSPBio_000386 • CHEBI:9629 • EINECS 201-040-3 • MLS002153880 • MLS002222215 • NSC 226903 • NSC 27592 • Prestwick3_000573 • Prestwick_473 • SCHEMBL335093 • SMR001233234 • Spirosolan-3-ol, (3beta,5alpha,22beta,25S)- • SR-05000002324 • Tomatidin • Tomatidine • tomatidine group • UNII-2B73S48786
CAS Number: 77-59-8
IUPAC Name: (1R,2S,4S,5'S,6S,7S,8R,9S,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-piperidine]-16-ol
PubChem CID: 65576

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Tomatidine

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Fang EF, et al. (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway Scientific reports () PubMed

DGIdb Human Drug-Gene Interactions for Tomatidine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Tomatidine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id