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DrugAge entry for Tocotrienol

Name
Tocotrienol 
Synonyms
(R)-3,4-Dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol • 2-methyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-1-benzopyran-6-ol • 2-Methyl-2-[[4,8,12-trimethyl-3(E),7(E),11(E)]-tridecatrienyl]-3,4-dihydro-2H-benzo[b]pyran-6-ol • 3,4-Dihydro-2-methyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol • 42152-EP2298776A1 • 42152-EP2311808A1 • 42152-EP2311829A1 • 6829-55-6 • 9074-33-3 • CCRIS 7711 • CHEMBL120643 • D03VFL • DB12647 • GJJVAFUKOBZPCB-ZGRPYONQSA-N • LS-153943 • NCGC00186586-01 • SCHEMBL1081622 • SCHEMBL1448780 • Tocotrienol 
CAS Number
6829-55-6 
IUPAC Name
2-methyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol 
PubChem CID
9929901 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Tocotrienol


References

Adachi, H and Ishii, N (2000) Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 55(6)B280-B285 PubMed
Collins, JJ et al. (2006) Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. Exp. Gerontol. 41(10)1032-1039 PubMed
Kashima, N et al. (2012) Development of a method for oral administration of hydrophobic substances to Caenorhabditis elegans: pro-longevity effects of oral supplementation with lipid-soluble antioxidants. Biogerontology 13(3)337-344 PubMed

DGIdb Human Drug-Gene Interactions for Tocotrienol

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Tocotrienol

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id