DrugAge entry for Thiostrepton

Name: Thiostrepton
Synonyms: 1393-48-2 • AKOS026750174 • Alaninamide, • Antibiotic 6761-31 • Antibiotic A 8506 • Antibiotic X 146 • BRD-K58049875-001-04-7 • Bryamycin • BSPBio_002468 • CAS-1393-48-2 • CCG-213336 • CHEBI:29693 • CHEMBL1236460 • CHEMBL410968 • DSSTox_CID_20625 • DSSTox_GSID_40625 • DSSTox_RID_79517 • EINECS 215-734-9 • HMS1569J05 • HMS2093I06 • HR4S203Y18 • NCGC00016576-01 • NCGC00096010-01 • NCGC00096010-02 • NSC 170365 • NSC 81722 • NSC-759821 • NSC759821 • Pharmakon1600-01505111 • Prestwick2_000522 • Q7784698 • SCHEMBL25847 • SPECTRUM1505111 • SR-05000001899 • Thiactin • thiostrepton • Thiostrepton [USP] • Tox21_110504 • UNII-HR4S203Y18 • X 146
CAS Number
IUPAC Name: N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(1R,8S,11Z,15S,18S,25S,26R,35R,37S,40S,46S,53S,59S)-37-[(2S)-butan-2-yl]-18-[(2S,3R)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8-[(1R)-1-hydroxyethyl]-31-[(1S)-1-hydroxyethyl]-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide
PubChem CID: 16154490

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Thiostrepton

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Thiostrepton

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Thiostrepton

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id