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DrugAge entry for Thioridazine hydrochloride

Name
Thioridazine hydrochloride 
Synonyms
10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride • 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride • 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine hydrochloride • 130-61-0 • 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine hydrochloride • Aldazine • CHEBI:48566 • EINECS 204-992-8 • Mellaril (TN) • Mellaril hydrochloride • Melleril (tablet) • MFCD00012655 • MLS000028408 • NSC 186060 • Ridazine • SBB057665 • SMR000058380 • Sonapax hydrochloride • Thioridazine (hydrochloride) • Thioridazine chloride • Thioridazine Hcl • Thioridazine hydrochloride • Thioridazine.HCl • USAF SZ-3 • USAF SZ-B 
CAS Number
130-61-0 
IUPAC Name
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride 
PubChem CID
66062 
SEP-L1000 side effects
Agitation, Agranulocytosis, Akathisia, Akinesia, Amenorrhoea, Anaemia, Angioedema, Aplastic anaemia, Arrhythmia, Asthma, Blood disorder, Body temperature increased, Breast engorgement, Breast feeding, Cardiac arrest, Cholestasis, Choreoathetosis, Confusional state, Constipation, Death, Decreased appetite, Dermatitis, Dermatitis contact, Dermatitis exfoliative, Diarrhoea, Dry mouth, Dyskinesia, Dystonia, Elderly, Eosinophilia, Erythema, Extrapyramidal disorder, Galactorrhoea, Gynaecomastia, Headache, Heart rate irregular, Hyperaemia, Hyperhidrosis, Hyperkinesia, Hyperpyrexia, Hypersensitivity, Hypotension, Ileus, Ileus paralytic, Incontinence, Jaundice, Laryngeal oedema, Lens disorder, Lethargy, Leukopenia, Menstruation irregular, Mental disorder, Miosis, Muscle rigidity, Nasal congestion, Nausea, Neuroleptic malignant syndrome, Oculogyric crisis, Oedema, Oedema peripheral, Opisthotonus, Pallor, Parotid gland enlargement, Photosensitivity reaction, Pigmentation disorder, Priapism, Protrusion tongue, Psychotic  

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Thioridazine hydrochloride


References

Ye, X et al. (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13(2)206-215 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Thioridazine hydrochloride

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Thioridazine hydrochloride

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id