DrugAge entry for Thapsigargin

Name: Thapsigargin
Synonyms: (-)-Thapsigargin • (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate • (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate • 67526-95-8 • AC1L9JLO • Azuleno[4,5-b]furan, octanoic acid deriv. • BSPBio_001501 • CHEBI:93212 • CHEBI:9516 • CHEMBL96926 • D02KGR • GTPL5351 • HMS1361L03 • HMS1791L03 • Lopac0_001262 • MFCD00083511 • MLS006010944 • MolPort-003-959-790 • n-7-yl ester (9CI) • OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z), 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER • Octanoic Acid [3s-[3alpha, 3abeta, 4alpha, 6beta,6abet
CAS Number: 67526-95-8
IUPAC Name
PubChem CID
SEP-L1000 side effects: Abdominal pain, Alopecia, Anaemia, Arthralgia, Asthenia, Body temperature increased, Constipation, Decreased appetite, Diarrhoea, Dizziness, Dyspnoea, Erythema, Fatigue, Flushing, Haemorrhage, Headache, Hypersensitivity, Infection, Leukopenia, Malaise, Myalgia, Nausea, Necrosis, Neuropathy peripheral, Oedema, Pain, Paraesthesia, Pruritus, Rash, Thrombocytopenia, Urticaria, Vertigo, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Thapsigargin

Average/Median Lifespan
Max Lifespan
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References

García-Casas, et al. (2018) Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms Frontiers in pharmacology () PubMed
García-Casas, P et al. (2021) Mechanism of the lifespan extension induced by submaximal SERCA inhibition in C. elegans. Mech Ageing Dev 196()111474 PubMed

DGIdb Human Drug-Gene Interactions for Thapsigargin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Thapsigargin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id