DrugAge entry for Tetramethylpyrazine

Name: Tetramethylpyrazine
Synonyms: 1124-11-4 • 2,3,5,6,-Tetramethyl-1,4-pyrazine • 2,3,5,6-Tetramethyl pyrazine • 2,3,5,6-Tetramethylpyrazine • 2,5,6-Tetramethylpyrazine • Bs factor • chuanxingzine • Chuanxiongzine • EINECS 214-391-2 • FEMA 3237 • FEMA No. 3237 • Ligustizine • Ligustrazine • Liqustrazine • MFCD00006146 • MLS000069594 • Pyrazine, 2,3,5,6-tetramethyl- • Pyrazine, tetramethyl- • SMR000059042 • Tetramethylpyrazin • TETRAMETHYLPYRAZINE • Tetrapyrazine • TMPZ • UNII-V80F4IA5XG • V80F4IA5XG
CAS Number: 1124-11-4
IUPAC Name: 2,3,5,6-tetramethylpyrazine
PubChem CID: 14296

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Tetramethylpyrazine

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Tetramethylpyrazine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Tetramethylpyrazine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id