DrugAge entry for Tetracycline HCL

Name: Tetracycline HCL
Synonyms: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride • 64-75-5 • 64-75-5 (HCl) • Achromycin • Achromycin hydrochloride • Bristacycline • DSSTox_CID_1321 • DSSTox_GSID_21321 • DSSTox_RID_76081 • Dumocyclin • Hostacycline • Mephacyclin • MFCD00078142 • P6R62377KV • Quadracycline • Quatrex • Sumycin • Supramycin • Sustamycin • Telotrex • Tetracycline (hydrochloride) • Tetracycline HCl • TETRACYCLINE HYDROCHLORIDE • Tetracyclinehydrochloride • UNII-P6R62377KV
CAS Number
IUPAC Name: (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
PubChem CID: 54704426

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Tetracycline HCL

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Tetracycline HCL

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Tetracycline HCL

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id