DrugAge entry for Tanespimycin

Name: Tanespimycin
Synonyms: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate • 17-(Allylamino)-17-demethoxygeldanamycin • 17-(Allylamino)geldanamycin • 17-AAG • 17-AAG (Tanespimycin) • 17-AG • 17-Allylaminogeldanamycin • 17-Demethoxy-17-allylamino geldanamycin • 17-N-allylamino-17-demethoxygeldanamycin • 17AAG • 4GY0AVT3L4 • 75747-14-7 • BMS-722782 • CHEBI:64153 • Cp 127374 • Geldanamycin, 17-(Allylamino)-17-demethoxy- • Geldanamycin, 17-demethoxy-17-(2-propenylamino)- • KOS-953 • NCGC00163424-01 • NSC 330507 • NSC-330507 • NSC330507 • Tanespimycin • UNII-4GY0AVT3L4 • [(3S,5S,6R,7S,8E,10R,11S,12E,14E)-6-Hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate
CAS Number: 75747-14-7
IUPAC Name: [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
PubChem CID: 6440175
SEP-L1000 side effects: Abdominal pain, Anaemia, Arrhythmia, Asthenia, Back pain, Body temperature increased, Confusional state, Constipation, Convulsion, Cough, Cushingoid, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Erythema, Headache, Hyperhidrosis, Hypersensitivity, Hypertension, Infection, Insomnia, Leukopenia, Malaise, Nausea, Oedema, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tachycardia, Thrombocytopenia, Urticaria, Vertigo, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Tanespimycin

Average/Median Lifespan
Max Lifespan
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References

Fuentealba, M et al. (2019) Using the drug-protein interactome to identify anti-ageing compounds for humans. PLoS Comput Biol 15(1)e1006639 PubMed
Janssens, GE et al. (2019) Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep 27(2)467-480.e6 PubMed

DGIdb Human Drug-Gene Interactions for Tanespimycin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Tanespimycin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id