DrugAge entry for TM5441 (PAI-1 inhibitor)

Name: TM5441 (PAI-1 inhibitor)
Synonyms: 1190221-43-2 • 5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid • 5-Chloro-2-(2-(2-(3-(furan-3-yl)phenylamino)-2-oxoethoxy)acetamido)benzoic acid • 5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid • 5-chloro-2-[[2-[2-[3-(furan-3-yl)anilino]-2-oxoethoxy]acetyl]amino]benzoic acid • AC-32578 • AKOS037648578 • BCP30131 • BS-14696 • CHEMBL4204253 • CS-6909 • EX-A2553 • HY-101761 • s6778 • SCHEMBL1016107 • TM 5441 • TM-5441 • ZINC115039082
CAS Number
IUPAC Name: 5-chloro-2-[[2-[2-[3-(furan-3-yl)anilino]-2-oxoethoxy]acetyl]amino]benzoic acid
PubChem CID: 44250349

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for TM5441 (PAI-1 inhibitor)

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Miller, RA et al. (2019) Glycine supplementation extends lifespan of male and female mice. Aging Cell 18(3)e12953 PubMed

DGIdb Human Drug-Gene Interactions for TM5441 (PAI-1 inhibitor)

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for TM5441 (PAI-1 inhibitor)

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id