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DrugAge entry for Sulindac Sulfide

Name
Sulindac Sulfide 
Synonyms
(Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-methyl-3H-inden-1-yl)acetic acid • (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid • (Z)-Sulindac sulfide • 1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)- • 2-[(3z)-6-Fluoranyl-2-Methyl-3-[(4-Methylsulfanylphenyl)methylidene]inden-1-Yl]ethanoic Acid • 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]acetic acid • 32004-67-4 • 49627-27-2 • 5-Fluoro-2-methyl-1-(p-methylthiobenzylidene)-3-indenyl acetic acid • 6UVA8S2DEY • CAS-49627-27-2 • CHEBI:75408 • CHEMBL18797 • DSSTox_CID_29004 • DSSTox_GSID_49078 • DSSTox_RID_83269 • EINECS 256-403-9 • MFCD00869764 • NCGC00161601-01 • Sulindac Related Compound C • Sulindac sulfide • Sulindac sulfide, (Z)- • Sulindac sulphide • UNII-6UVA8S2DEY • UPCMLD-DP020 • {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid 
CAS Number
49627-27-2 
IUPAC Name
2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]acetic acid 
PubChem CID
5352624 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Sulindac Sulfide


References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Sulindac Sulfide

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Sulindac Sulfide

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id