DrugAge entry for Spermine

Name: Spermine
Synonyms: 1,4-Bis(aminopropyl) butanediamine • 1,4-Bis(aminopropyl)butanediamine • 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- • 1,4-Diaminobutane, N,N'-bis(3-aminopropyl)- • 4,9-Diaza-1,12-dodecanediamine • 4,9-Diazadodecamethylenediamine • 4,9-Diazadodecane-1,12-diamine • 71-44-3 • AI3-26633 • BRN 1750791 • CHEBI:15746 • CHEMBL23194 • Diaminopropyltetramethylenediamine • EINECS 200-754-2 • gerontine • musculamine • N,N'-Bis(3-aminopropyl)-1,4-butanediamine • N,N'-Bis(3-aminopropyl)butane-1,4-diamine • N1,N1'-(Butane-1,4-diyl)bis(propane-1,3-diamine) • neuridine • NSC 268508 • Spermin • spermine • Spermine Derivative • Spermine, puriss
CAS Number: 71-44-3
IUPAC Name: N,N'-bis(3-aminopropyl)butane-1,4-diamine
PubChem CID: 1103

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Spermine

Average/Median Lifespan
Max Lifespan
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References

Eisenberg T, et al. (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine Nature Medicine () PubMed

DGIdb Human Drug-Gene Interactions for Spermine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Spermine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id