DrugAge entry for Spermidine

Name: Spermidine
Synonyms: (4-aminobutyl)(3-aminopropyl)amine • 1,4-Butanediamine, N-(3-aminopropyl)- • 1,4-Butanediamine, N1-(3-aminopropyl)- • 1,4-Diaminobutane, N-(3-aminopropyl)- • 1,5,10-Triazadecane • 1,8-Diamino-4-azaoctane • 124-20-9 • 4-Azaoctamethylenediamine • 4-Azaoctane-1,8-diamine • AI3-26636 • ATHGHQPFGPMSJY-UHFFFAOYSA-N • BRN 1698591 • CHEBI:16610 • CHEMBL19612 • EINECS 204-689-0 • MFCD00008229 • N'-(3-aminopropyl)butane-1,4-diamine • N-(3-Aminopropyl)-1,4-butane-diamine • N-(3-Aminopropyl)-1,4-butanediamine • N-(3-Aminopropyl)-1,4-diaminobutane • N-(3-aminopropyl)butane-1,4-diamine • N-[3-Aminopropyl]-1,4-butanediamine • N1-(3-Aminopropyl)butane-1,4-diamine • Spermidin • spermidine
CAS Number: 124-20-9
IUPAC Name: N'-(3-aminopropyl)butane-1,4-diamine
PubChem CID: 1102
SEP-L1000 side effects: Anxiety, Body temperature increased, Confusional state, Diarrhoea, Dizziness, Dry mouth, Dyspepsia, Headache, Hepatitis, Hypersensitivity, Hypotension, Insomnia, Muscle spasms, Myalgia, Nausea, Oedema, Orthostatic hypotension, Pain, Paraesthesia, Pruritus, Rash, Somnolence, Tinnitus, Tremor, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Spermidine

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Eisenberg, T et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11(11)1305-1314 PubMed
Zsolt Datki (2019) Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers Molecules 24(11)2171 PubMed
Eisenberg T, et al. (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine Nature Medicine () PubMed
Yue F, et al. (2017) Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy Cancer Research () PubMed

DGIdb Human Drug-Gene Interactions for Spermidine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Spermidine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id