DrugAge entry for Sorbitol
- Name
- Sorbitol
- Synonyms
- (-)-Sorbitol • 50-70-4 • Cholaxine • D-(-)-Sorbitol • D-Glucitol • D-Sorbitol • Diakarmon • Esasorb • Glucarine • glucitol • Karion • Karion instant • L-Gulitol • Multitol • Neosorb • Nivitin • Sionit • Sionite • Sionon • Siosan • Sorbilande • Sorbite • sorbitol • Sorbol • Sorbostyl
- CAS Number
- 50-70-4
- IUPAC Name
- (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol
- PubChem CID
- 5780
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Sorbitol
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Kaeberlein, M et al. (2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol. Cell. Biol. 22(22)8056-8066 PubMedLee, SJ et al. (2009) Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10(5)379-391 PubMed
Chandler-Brown, et al. (2015) Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans () PubMed
Anderson N, et al. (2016) C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins Mech Ageing Dev () PubMed
DGIdb Human Drug-Gene Interactions for Sorbitol
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Sorbitol
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
|---|