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DrugAge entry for Simvastatin

Name
Simvastatin 
Synonyms
79902-63-9 • Cholestat • Coledis • Colemin • Denan • Labistatin • Lipex • Lodales • Medipo • MK-733 • Nivelipol • Pantok • Rendapid • Simovil • simvastatin • Simvastatin lactone • Simvastatina • Simvastatine • Simvastatinum • Sinvacor • Sivastin • Synvinolin • Vasotenal • Velostatin • Zocor 
CAS Number
79902-63-9 
IUPAC Name
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate 
PubChem CID
54454 
SEP-L1000 side effects
Abdominal pain, Alopecia, Amnesia, Anaemia, Anaphylactic shock, Angioedema, Antinuclear antibody positive, Anxiety, Arthralgia, Arthritis, Asthenia, Atrial fibrillation, Blood alkaline phosphatase increased, Body temperature increased, Bronchitis, Cardiac fibrillation, Cataract, Chills, Cognitive disorder, Confusional state, Constipation, Decreased appetite, Diarrhoea, Dizziness, Drug interaction, Dysgeusia, Dyspepsia, Dyspnoea, Eczema, Endocrine disorder, Eosinophilia, Erectile dysfunction, Erythema, Erythema multiforme, Flatulence, Flushing, Gastritis, Gastrointestinal disorder, Gynaecomastia, Haemolytic anaemia, Headache, Hepatic cirrhosis, Hepatic failure, Hepatic function abnormal, Hepatic necrosis, Hepatic steatosis, Hepatitis, Hypersensitivity, Ichthyosis, Infection, Insomnia, Interstitial lung disease, Jaundice, Jaundice cholestatic, Lens disorder, Lenticular opacities, Leukopenia, Loss of libido, Lung disorder, Malaise, Memory impairment, Mental disorder, Muscle spasms, Muscular weakness, Musculoskel 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Simvastatin


References

Spindler, SR et al. (2012) Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. PLoS ONE 7(6)e39581 PubMed
Jahn, A et al. (2020) Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in Aging Dis 11(1)60-72 PubMed
Miller, RA et al. (2011) Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. The journals of gerontology. Series A, Biological sciences and medical sciences 66(2)191-201 PubMed

DGIdb Human Drug-Gene Interactions for Simvastatin

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Simvastatin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id